聚维酮碘溶液作为 SARS-CoV-2 预防措施在上呼吸道程序中的理论框架。
Povidone-iodine solution as SARS-CoV-2 prophylaxis for procedures of the upper aerodigestive tract a theoretical framework.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 5.036, Houston, TX, 77030, USA.
Department of Anesthesiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
出版信息
J Otolaryngol Head Neck Surg. 2020 Oct 27;49(1):77. doi: 10.1186/s40463-020-00474-x.
BACKGROUND
The COVID-19 pandemic has raised concerns of inadvertent SARS-CoV-2 transmission to healthcare workers during routine procedures of the aerodigestive tract in asymptomatic COVID-19 patients. Current efforts to mitigate this risk focus on Personal Protective Equipment, including high-efficiency filtration as well as other measures. Because the reservoir for SARS-CoV-2 shedding is in the nasopharynx and nasal and oral cavities, the application of viricidal agents to these surfaces may reduce virus burden. Numerous studies have confirmed that povidone-iodine inactivates many common respiratory viruses, including SARS-CoV-1. Povidone-iodine also has good profile for mucosal tolerance. Thus, we propose a prophylactic treatment protocol for the application of topical povidone-iodine to the upper aerodigestive tract.
CONCLUSION
Such an approach represents a low-cost, low-morbidity measure that may reduce the risks associated with aerosol-generating procedures performed commonly in otorhinolaryngology operating rooms.
背景
COVID-19 大流行引发了人们的担忧，即在无症状 COVID-19 患者的呼吸道常规操作过程中，无意中将 SARS-CoV-2 传播给医护人员。目前，为降低这种风险，主要采取个人防护设备，包括高效过滤以及其他措施。因为 SARS-CoV-2 的储库位于鼻咽部以及鼻腔和口腔，所以在这些表面应用杀病毒剂可能会降低病毒载量。许多研究已经证实，聚维酮碘可以灭活许多常见的呼吸道病毒，包括 SARS-CoV-1。聚维酮碘对粘膜也具有良好的耐受性。因此，我们提出了一种预防性治疗方案，即将局部聚维酮碘应用于上呼吸道。
结论
这种方法代表了一种低成本、低发病率的措施，可能会降低耳鼻喉科手术室中常见的产生气溶胶的操作相关的风险。
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