DNA 甲基化钟在衰老研究中的应用。
The use of DNA methylation clock in aging research.
机构信息
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, 66367Zunyi Medical University, Zunyi 563003, China.
出版信息
Exp Biol Med (Maywood). 2021 Feb;246(4):436-446. doi: 10.1177/1535370220968802. Epub 2020 Nov 11.
One of the key characteristics of aging is a progressive loss of physiological integrity, which weakens bodily functions and increases the risk of death. A robust biomarker is important for the assessment of biological age, the rate of aging, and a person's health status. DNA methylation clocks, novel biomarkers of aging, are composed of a group of cytosine-phosphate-guanine dinucleotides, the DNA methylation status of which can be used to accurately measure subjective age. These clocks are considered accurate biomarkers of chronological age for humans and other vertebrates. Numerous studies have demonstrated these clocks to quantify the rate of biological aging and the effects of longevity and anti-aging interventions. In this review, we describe the purpose and use of DNA methylation clocks in aging research.
衰老的一个关键特征是生理完整性的逐渐丧失，这削弱了身体功能并增加了死亡的风险。一个强大的生物标志物对于评估生物年龄、衰老速度和一个人的健康状况非常重要。DNA 甲基化时钟是衰老的新生物标志物，由一组胞嘧啶-磷酸-鸟嘌呤二核苷酸组成，其 DNA 甲基化状态可用于准确测量主观年龄。这些时钟被认为是人类和其他脊椎动物的准确生物钟标志物。许多研究表明，这些时钟可以量化生物衰老的速度以及长寿和抗衰老干预的效果。在这篇综述中，我们描述了 DNA 甲基化时钟在衰老研究中的目的和用途。
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