非酒精性脂肪性肝病 (NAFLD) 中生活方式干预的病理生理学。

Institute of Biomedicine of Seville (IBIS), Spanish National Research Council (CSIC), University of Seville, Virgen del Rocio University Hospital, 41013 Seville, Spain.

Centro Andaluz de Biología del Desarrollo (CABD/CSIC/JA), Institute of Health Carlos III (CIBERER), University of Pablo de Olavide, 41013 Sevilla, Spain.

Nutrients. 2020 Nov 12;12(11):3472. doi: 10.3390/nu12113472.

Non-alcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years. Diet and exercise interventions are the first-line treatment options, with weight loss via a hypocaloric diet being the most important therapeutic target in NAFLD. However, most NAFLD patients are not able to achieve such weight loss. Therefore, the requisite is the investigation of other effective therapeutic approaches. This review summarizes research on understanding complex pathophysiology underlying dietary approaches and exercise interventions with the potential to prevent and treat NAFLD.

非酒精性脂肪性肝病（NAFLD）是一个主要的健康问题，近年来其患病率有所增加。饮食和运动干预是一线治疗选择，通过低热量饮食减轻体重是非酒精性脂肪性肝病最重要的治疗目标。然而，大多数非酒精性脂肪性肝病患者无法实现如此体重减轻。因此，需要研究其他有效的治疗方法。本综述总结了对饮食方法和运动干预的潜在预防和治疗非酒精性脂肪性肝病的复杂病理生理学的研究。