天然生物聚合物复合材料的合成及生物医学性能的最新进展。
Recent Progress in the Synthesis and Biomedical Properties of Natural Biopolymer Composites.
机构信息
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Jinan 250353,China.
Department of Chemistry, the Ångström Laboratory, Uppsala University, 75121 Uppsala,Sweden.
出版信息
Curr Med Chem. 2021;28(40):8243-8266. doi: 10.2174/0929867328666201217104038.
BACKGROUND
Natural biopolymers have drawn extensive attention because of their great biocompatibility, biodegradability, renewability, and the availability of various reactive functional groups for modifying and introducing novel components. In the last few years, numerous natural biopolymer composites have been exploited to improve their physical and chemical properties and add new functionalities.
METHODS
Herein, we summarize the current progress in three common classes of natural biopolymer-based composites, including alginate, chitosan, and gelatin.
RESULTS
The morphology characteristics, preparation methods, and unique functionalities of these biopolymer composites are also analyzed and discussed.
CONCLUSION
Finally, the article offers an overview of recent progress in the main biomedical applications such as tissue engineering, wound-healing, and drug delivery, which inspires further progress in biopolymer composites with tailored mechanical property and stable characteristics for pharmaceutical and biomedical applications.
背景
由于具有良好的生物相容性、可生物降解性、可再生性以及存在各种反应性官能团可用于修饰和引入新型成分，天然生物聚合物引起了广泛关注。在过去的几年中，已经开发出了许多天然生物聚合物复合材料，以改善它们的物理和化学性质并添加新的功能。
方法
本文总结了三种常见的天然生物聚合物基复合材料，包括藻酸盐、壳聚糖和明胶的最新进展。
结果
还分析和讨论了这些生物聚合物复合材料的形态特征、制备方法和独特功能。
结论
最后，本文概述了在组织工程、伤口愈合和药物输送等主要生物医学应用中的最新进展，这激发了具有定制机械性能和稳定特性的生物聚合物复合材料在药物和生物医学应用中的进一步发展。
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