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氯化溶剂:在有机和药物化学中的优缺点及替代品。

Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and Medicinal Chemistry.

机构信息

GlaxoSmithKline Carbon Neutral Laboratory for Sustainable Chemistry, Jubilee Campus, University of Nottingham, 6 Triumph Road, Nottingham NG7 2GA, U.K.

Drug Design and Selection, Platform and Technology Sciences, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States.

出版信息

Chem Rev. 2021 Feb 10;121(3):1582-1622. doi: 10.1021/acs.chemrev.0c00709. Epub 2020 Dec 22.

Abstract

Chlorinated solvents were once, and in many places are still, ubiquitous in chemistry laboratories. This review explores the properties that led to such widespread use, why there is now an increasing drive to minimize usage, and what alternatives are currently available.

摘要

氯代溶剂曾经在许多地方广泛应用于化学实验室中。本综述探讨了导致其广泛使用的性质,为什么现在越来越需要减少使用,以及目前可用的替代物。

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