重庆11例2019新型冠状病毒感染患儿的流行病学及临床特征分析：一项单中心回顾性研究
Epidemiological and clinical characteristics analysis of 11 children with 2019 novel coronavirus infection in Chongqing: a single-center retrospective study.
作者信息
Chen Qiang, Tian Xiuying, Luo Yarui, Liu Jun, Jiang Li, Feng Xiaoqian, Chen Zongwen
机构信息
Department of Pediatrics, Chongqing University Three Gorges Hospital, Chongqing, China.
出版信息
Transl Pediatr. 2020 Dec;9(6):818-826. doi: 10.21037/tp-20-429.
BACKGROUND
The global epidemic of the 2019 novel coronavirus (2019-nCoV) is still going on. This article shares information about the infected children from a treatment center in Chongqing, China.
METHODS
A retrospective analysis of the epidemiology, clinical symptoms, signs, laboratory examinations, chest computed tomography results, treatment effect of 11 children infected by 2019-nCoV was performed. Children were diagnosed from January 25 to February 29, 2020 in Chongqing University Three Gorges Hospital.
RESULTS
The mean age of the 11 children with 2019-nCoV infection was 11 years and 5 months. Two cases (18%) were imported cases from Wuhan. The 9 cases (82%) were family cluster cases. There were 5 asymptomatic type cases (45%), 2 mild cases (18%), and 4 common type cases (37%). The most common symptom was fever (5 cases), cough (3 cases), sore throat (1 case) and diarrhea (1 case). There were abnormal chest CT changes in 6 cases, including 4 cases with patchy ground-glass opacities and 2 cases with thickened lung texture. Laboratory tests showed that procalcitonin increased in 4 cases (36%), and C-reactive protein (CRP) increased in 1 case (9%). In lymphocyte subgroup examination, lymphocyte count increased in 2 cases (18%) and decreased in 1 case (9%); T%, cluster of differentiation 8 (CD8)+ T%, and natural killer (NK) cell% were normal in 11 cases; CD4+ T% was increased in 2 cases (18%), and CD4+ T%/CD8+ T% was decreased in 1 case (9%); B% was increased in 1 case (9%). The interleukin 4 (IL-4), IL-10, and IL-17 in 11 cases were normal; IL-6 was increased in 7 cases (64%); tumor necrosis factor-alpha (TNF-α) was increased in 1 case (9%); and interferon gamma (IFN-γ) was increased in 6 cases (55%). All patients had been discharged from the hospital.
CONCLUSIONS
Children are generally susceptible to 2019-nCoV, and the main way of infection is close contact with an infected person in the family. Clinical symptoms are mild. Laboratory and chest CT examinations are not as typical as those of adults. The prognosis is generally good. The unique immune function of children may help fight the new coronavirus.
背景
2019新型冠状病毒（2019-nCoV）全球疫情仍在持续。本文分享了来自中国重庆一家治疗中心的儿童感染病例信息。
方法
对重庆三峡中心医院2020年1月25日至2月29日确诊的11例2019-nCoV感染儿童的流行病学、临床症状、体征、实验室检查、胸部计算机断层扫描结果及治疗效果进行回顾性分析。
结果
11例2019-nCoV感染儿童的平均年龄为11岁5个月。2例（18%）为武汉输入病例。9例（82%）为家庭聚集性病例。无症状型5例（45%），轻型2例（18%），普通型4例（37%）。最常见症状为发热（5例）、咳嗽（3例）、咽痛（1例）及腹泻（1例）。6例胸部CT有异常改变，其中4例表现为斑片状磨玻璃影，2例表现为肺纹理增粗。实验室检查显示，4例（36%）降钙素原升高，1例（9%）C反应蛋白（CRP）升高。淋巴细胞亚群检查中，2例（18%）淋巴细胞计数升高，1例（9%）降低；11例T%、分化簇8（CD8）+T%及自然杀伤（NK）细胞%正常；2例（18%）CD4+T%升高，1例（9%）CD4+T%/CD8+T%降低；1例（9%）B%升高。11例白细胞介素4（IL-4）、IL-10及IL-17正常；7例（64%）IL-6升高；1例（9%）肿瘤坏死因子-α（TNF-α）升高；6例（55%）干扰素-γ（IFN-γ）升高。所有患者均已出院。
结论
儿童对2019-nCoV普遍易感，主要感染途径为家庭内与感染者密切接触。临床症状较轻。实验室及胸部CT检查表现不如成人典型。预后总体良好。儿童独特的免疫功能可能有助于对抗新型冠状病毒。
Zotero 插件