Division of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
PLoS One. 2021 Mar 18;16(3):e0248762. doi: 10.1371/journal.pone.0248762. eCollection 2021.
Determine the cost-effectiveness of three financial incentive structures in obtaining a 1% within group drop in HbA1c among adults with diabetes.
60 African Americans with type 2 diabetes were randomized to one of three financial incentive structures and followed for 3-months. Group 1 (low frequency) received a single incentive for absolute HbA1c reduction, Group 2 (moderate frequency) received a two-part incentive for home testing of glucose and absolute HbA1c reduction and Group 3 (high frequency) received a multiple component incentive for home testing, attendance of weekly telephone education classes and absolute HbA1c reduction. The primary clinical outcome was HbA1c reduction within each arm at 3-months. Cost for each arm was calculated based on the cost of the intervention, cost of health care visits during the 3-month time frame, and cost of workdays missed from illness. Incremental cost effectiveness ratios (ICER) were calculated based on achieving a 1% within group drop in HbA1c and were bootstrapped with 1,000 replications.
The ICER to decrease HbA1c by 1% was $1,100 for all three arms, however, bootstrapped standard errors differed with Group 1 having twice the variation around the ICER coefficient as Groups 2 and 3. ICERs were statistically significant for Groups 2 and 3 (p<0.001) indicating they are cost effective interventions.
Given ICERs of prior diabetes interventions range from $1,000-$4,000, a cost of $1,100 per 1% within group decrease in HbA1c is a promising intervention. Multi-component incentive structures seem to have the least variation in cost-effectiveness.
确定三种财务激励结构在降低成年糖尿病患者 HbA1c 组内 1%方面的成本效益。
60 名非裔美国 2 型糖尿病患者被随机分配到三种财务激励结构中的一种,并随访 3 个月。第 1 组(低频率)获得 HbA1c 绝对值降低的单一激励,第 2 组(中频率)获得家庭血糖测试和 HbA1c 绝对值降低的两部分激励,第 3 组(高频率)获得家庭测试、每周电话教育课程和 HbA1c 绝对值降低的多部分激励。主要临床结局为每组 3 个月时 HbA1c 的降低。根据干预成本、3 个月内医疗就诊成本和因病缺勤工作日成本计算每个组的成本。基于实现 HbA1c 组内降低 1%的增量成本效益比(ICER)进行计算,并通过 1000 次重复进行自举。
三组降低 HbA1c 1%的 ICER 均为 1100 美元,但第 1 组的 ICER 系数周围的标准误差变化是第 2 组和第 3 组的两倍。第 2 组和第 3 组的 ICER 具有统计学意义(p<0.001),表明它们是具有成本效益的干预措施。
鉴于先前糖尿病干预措施的 ICER 范围为 1000-4000 美元,HbA1c 组内降低 1%的成本为 1100 美元是一种很有前途的干预措施。多因素激励结构在成本效益方面的变化似乎最小。