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热天气与不良心理健康结果之间是否存在关联?系统评价和荟萃分析。

Is there an association between hot weather and poor mental health outcomes? A systematic review and meta-analysis.

机构信息

School of Public Health, The University of Adelaide, Australia.

School of Public Health, The University of Adelaide, Australia; School of Public Health, Fujian Medical University, China.

出版信息

Environ Int. 2021 Aug;153:106533. doi: 10.1016/j.envint.2021.106533. Epub 2021 Mar 30.

Abstract

BACKGROUND

Mental health is an important public health issue globally. A potential link between heat exposure and mental health outcomes has been recognised in the scientific literature; however, the associations between heat exposure (both high ambient temperatures and heatwaves) and mental health-related mortality and morbidity vary between studies and locations.

OBJECTIVE

To fill gaps in knowledge, this systematic review aims to summarize the epidemiological evidence and investigate the quantitative effects of high ambient temperatures and heatwaves on mental health-related mortality and morbidity outcomes, while exploring sources of heterogeneity.

METHODS

A systematic search of peer-reviewed epidemiological studies on heat exposure and mental health outcomes published between January 1990 and November 2020 was conducted using five databases (PubMed, Embase, Scopus, Web of Science and PsycINFO). We included studies that examined the association between high ambient temperatures and/or heatwaves and mental health-related mortality and morbidity (e.g. hospital admissions and emergency department visits) in the general population. A range of mental health conditions were defined using ICD-10 classifications. We performed random effects meta-analysis to summarize the relative risks (RRs) in mental health outcomes per 1 °C increase in temperature, and under different heatwaves definitions. We further evaluated whether variables such as age, sex, socioeconomic status, and climate zone may explain the observed heterogeneity.

RESULTS

The keyword search yielded 4560 citations from which we identified 53 high temperatures/heatwaves studies that comprised over 1.7 million mental health-related mortality and 1.9 million morbidity cases in total. Our findings suggest associations between heat exposures and a range of mental health-related outcomes. Regarding high temperatures, our meta-analysis of study findings showed that for each 1 °C increase in temperature, the mental health-related mortality and morbidity increased with a RR of 1.022 (95%CI: 1.015-1.029) and 1.009 (95%CI: 1.007-1.015), respectively. The greatest mortality risk was attributed to substance-related mental disorders (RR, 1.046; 95%CI: 0.991-1.101), followed by organic mental disorders (RR, 1.033; 95%CI: 1.020-1.046). A 1 °C temperature rise was also associated with a significant increase in morbidity such as mood disorders, organic mental disorders, schizophrenia, neurotic and anxiety disorders. Findings suggest evidence of vulnerability for populations living in tropical and subtropical climate zones, and for people aged more than 65 years. There were significant moderate and high heterogeneities between effect estimates in overall mortality and morbidity categories, respectively. Lower heterogeneity was noted in some subgroups. The magnitude of the effect estimates for heatwaves varied depending on definitions used. The highest effect estimates for mental health-related morbidity was observed when heatwaves were defined as "mean temperature ≥90th percentile for ≥3 days" (RR, 1.753; 95%CI: 0.567-5.421), and a significant effect was also observed when the definition was "mean temperature ≥95th percentile for ≥3 days", with a RR of 1.064 (95%CI: 1.006-1.123).

CONCLUSIONS

Our findings support the hypothesis of a positive association between elevated ambient temperatures and/or heatwaves and adverse mental health outcomes. This problem will likely increase with a warming climate, especially in the context of climate change. Further high-quality studies are needed to identify modifying factors of heat impacts.

摘要

背景

心理健康是全球重要的公共卫生问题。科学文献已经认识到热暴露与心理健康结果之间存在潜在联系;然而,热暴露(包括高环境温度和热浪)与心理健康相关死亡率和发病率之间的关联在不同的研究和地点之间存在差异。

目的

为了填补知识空白,本系统综述旨在总结流行病学证据,并调查高环境温度和热浪对心理健康相关死亡率和发病率的定量影响,同时探索异质性的来源。

方法

使用五个数据库(PubMed、Embase、Scopus、Web of Science 和 PsycINFO)对 1990 年 1 月至 2020 年 11 月期间发表的关于热暴露与心理健康结果的同行评审流行病学研究进行了系统搜索。我们纳入了研究高环境温度和/或热浪与一般人群心理健康相关死亡率和发病率(例如住院和急诊就诊)之间关系的研究。使用 ICD-10 分类定义了一系列心理健康状况。我们进行了随机效应荟萃分析,以总结每升高 1°C 时,在不同的热浪定义下,精神健康结果的相对风险(RR)。我们还评估了年龄、性别、社会经济地位和气候带等变量是否可以解释观察到的异质性。

结果

关键词搜索从 4560 条引文中共确定了 53 项高温/热浪研究,这些研究总共包括超过 170 万例与心理健康相关的死亡率和 190 万例发病率病例。我们的研究结果表明热暴露与一系列心理健康相关结果之间存在关联。关于高温,我们对研究结果的荟萃分析表明,每升高 1°C,精神健康相关死亡率和发病率分别增加 1.022(95%CI:1.015-1.029)和 1.009(95%CI:1.007-1.015)的 RR。最大的死亡率风险归因于与物质相关的精神障碍(RR,1.046;95%CI:0.991-1.101),其次是与有机相关的精神障碍(RR,1.033;95%CI:1.020-1.046)。气温升高还与情绪障碍、有机精神障碍、精神分裂症、神经症和焦虑症等发病率显著增加有关。研究结果表明,居住在热带和亚热带气候区的人群以及年龄超过 65 岁的人群存在脆弱性证据。在总体死亡率和发病率类别中,效应估计值之间存在显著的中度和高度异质性。在一些亚组中注意到较低的异质性。热浪对心理健康相关发病率的影响估计值的幅度取决于使用的定义。当热浪定义为“≥3 天平均温度≥第 90 百分位数”时,观察到与心理健康相关的发病率的最高影响估计值(RR,1.753;95%CI:0.567-5.421),当定义为“≥3 天平均温度≥第 95 百分位数”时,也观察到显著的影响,RR 为 1.064(95%CI:1.006-1.123)。

结论

我们的研究结果支持了升高的环境温度和/或热浪与不良心理健康结果之间存在正相关的假设。随着气候变暖,特别是在气候变化的背景下,这个问题可能会加剧。需要进一步进行高质量的研究,以确定热影响的调节因素。

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