产后睡眠缺失与加速的表观遗传衰老。
Postpartum sleep loss and accelerated epigenetic aging.
机构信息
Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
出版信息
Sleep Health. 2021 Jun;7(3):362-367. doi: 10.1016/j.sleh.2021.02.002. Epub 2021 Apr 24.
BACKGROUND
Insufficient sleep has been linked to accelerated biological aging in adults, providing a possible mechanism through which sleep may influence disease risk. In the current paper, we test the hypothesis that short sleep in postpartum would predict older biological age in women one year post birth, as indicated by accelerated epigenetic aging.
METHODS
As part of a larger study of pregnancy and postpartum health (Healthy Babies Before Birth, HB3), 33 mothers provided blood samples for epigenetic aging clock estimates. intrinsic epigenetic age acceleration (IEAA), extrinsic apigenetic age acceleration, phenotypic epigenetic age acceleration (PEAA), GrimAge, DNAmPAI-1, and DNAm telomere length (TL) were calculated using established protocols. Sleep duration was categorized as insufficient sleep (<7 hours per night) or healthy sleep duration (7+ hours per night). Sleep quality was determined using the Pittsburgh Sleep Quality Index (Global score >5).
RESULTS
Maternal postpartum sleep duration at 6 months, but not 12 months, following a birth was predictive of older 12-month IEAA, B (SE) = 3.0 (1.2), P = .02, PEAA, B (SE) = 7.3 (2.0), P = .002, and DNAmTL, B (SE) = -0.18 (0.07), P = .01, but not other indices, all P> .127. Self-reported poor sleep quality at 6 and 12 months was not significantly related to epigenetic age.
CONCLUSIONS
These findings suggest that insufficient sleep duration during the early postpartum period is associated with accelerated biological aging. As the sample size is small, additional research is warranted with a larger sample size to replicate these findings.
背景
睡眠不足与成年人的生物衰老加速有关，这为睡眠可能影响疾病风险提供了一种可能的机制。在目前的论文中，我们检验了这样一个假设，即产后睡眠不足会预测女性产后一年的生物年龄更大，这表现为表观遗传衰老加速。
方法
作为一项关于妊娠和产后健康的更大研究（健康婴儿出生前，HB3）的一部分，33 名母亲提供了血液样本，用于估计表观遗传衰老时钟。内在表观遗传年龄加速（IEAA）、外在表观遗传年龄加速、表型表观遗传年龄加速（PEAA）、GrimAge、DNAmPAI-1 和 DNAm 端粒长度（TL）使用既定的方案进行计算。睡眠持续时间分为睡眠不足（每晚<7 小时）或健康睡眠持续时间（每晚 7 小时以上）。使用匹兹堡睡眠质量指数（全球评分>5）确定睡眠质量。
结果
产后 6 个月而不是 12 个月的母亲睡眠持续时间与 12 个月时更大的 12 个月 IEAA 相关，B（SE）=3.0（1.2），P=0.02，PEAA，B（SE）=7.3（2.0），P=0.002，以及 DNAmTL，B（SE）=-0.18（0.07），P=0.01，但其他指数均不相关，所有 P>0.127。6 个月和 12 个月时自我报告的睡眠质量差与表观遗传年龄无显著相关性。
结论
这些发现表明，产后早期睡眠持续时间不足与生物衰老加速有关。由于样本量较小，需要更大的样本量进行额外的研究来复制这些发现。
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