全球咳嗽的生理学和病理生理学：第 2 部分。人口统计学和临床注意事项：CHEST 专家小组报告。
Global Physiology and Pathophysiology of Cough: Part 2. Demographic and Clinical Considerations: CHEST Expert Panel Report.
机构信息
Wellcome-Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland.
Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA.
出版信息
Chest. 2021 Oct;160(4):1413-1423. doi: 10.1016/j.chest.2021.04.039. Epub 2021 Apr 24.
BACKGROUND
Cough characteristics vary between patients, and this can impact clinical diagnosis and care. The purpose of part two of this state-of-the-art review is to update the American College of Chest Physicians (CHEST) 2006 guideline on global physiology and pathophysiology of cough.
STUDY DESIGN AND METHODS
A review of the literature was conducted using PubMed and MEDLINE databases from 1951 to 2019 using prespecified search terms.
RESULTS
We describe the demographics of typical patients with cough in the clinical setting, including how cough characteristics change across age. We summarize the effect of common clinical conditions impacting cough mechanics and the physical properties of mucus on airway clearance.
INTERPRETATION
This is the second of a two-part update to the 2006 CHEST cough guideline; it complements part one on basic phenomenology of cough by providing an extended clinical picture of cough along with the factors that alter cough mechanics and efficiency in patients. A greater understanding of the physiology and pathophysiology of cough will improve clinical management.
背景
咳嗽特征在患者之间存在差异，这可能会影响临床诊断和治疗。本文是该领域最新综述的第二部分，旨在更新美国胸科学会（CHEST）2006 年关于咳嗽的全球生理学和病理生理学指南。
研究设计和方法
使用 PubMed 和 MEDLINE 数据库，从 1951 年到 2019 年，使用预设的检索词进行文献回顾。
结果
我们描述了临床环境中典型咳嗽患者的人口统计学特征，包括咳嗽特征随年龄的变化。我们总结了影响咳嗽力学和黏液物理性质的常见临床情况对气道清除的影响。
结论
这是对 2006 年 CHEST 咳嗽指南的第二部分更新；它通过提供咳嗽的扩展临床图片以及改变患者咳嗽力学和效率的因素，补充了第一部分关于咳嗽基本现象学的内容。对咳嗽生理学和病理生理学的更深入了解将改善临床管理。
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