Cu/SiO-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution.

In this work, an innovative nanocatalyst (Cu/SiO-Pr-NH-Benz) was synthesized and applied to coupling and click reaction in an aqueous solution. This work reports an efficient and straightforward approach for synthesizing diverse propargylamine and 1,2,3-triazole derivatives in excellent yield and short-time reaction. Also, a novel method involving the Cu NPs supported on the SiO nanocatalyst as a heterogeneous novel catalyst for the "" three-component A-coupling of aldehyde, amine, and alkynes and "" click reaction between alkyne, benzyl halide, and sodium azide in the water at room temperature was developed. Significant advantageous such as enhanced catalytic activity with efficient recycling for the one-pot synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives and in green condition were observed. Also, after five successive reactions, the catalytic activity of recycled Cu/SiO-Pr-NH-Benz remained high without significant loss in its intrinsic activity.