乳酸耐受性的潜在机制及其对（某生物）乳酸产生的影响 。 需注意，原文最后“in.”后面似乎缺少具体内容。
Mechanisms underlying lactic acid tolerance and its influence on lactic acid production in .
作者信息
Peetermans Arne, Foulquié-Moreno María R, Thevelein Johan M
机构信息
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Flanders, Belgium.
Center for Microbiology, VIB, Kasteelpark Arenberg 31, B-3001, Leuven-Heverlee, Flanders, Belgium.
出版信息
Microb Cell. 2021 Apr 14;8(6):111-130. doi: 10.15698/mic2021.06.751.
Abstract
One of the major bottlenecks in lactic acid production using microbial fermentation is the detrimental influence lactic acid accumulation poses on the lactic acid producing cells. The accumulation of lactic acid results in many negative effects on the cell such as intracellular acidification, anion accumulation, membrane perturbation, disturbed amino acid trafficking, increased turgor pressure, ATP depletion, ROS accumulation, metabolic dysregulation and metal chelation. In this review, the manner in which deals with these issues will be discussed extensively not only for lactic acid as a singular stress factor but also in combination with other stresses. In addition, different methods to improve lactic acid tolerance in using targeted and non-targeted engineering methods will be discussed.
摘要
利用微生物发酵生产乳酸的主要瓶颈之一是乳酸积累对产乳酸细胞产生的有害影响。乳酸的积累会对细胞产生许多负面影响，如细胞内酸化、阴离子积累、膜扰动、氨基酸转运紊乱、膨压增加、ATP消耗、活性氧积累、代谢失调和金属螯合。在本综述中，不仅将广泛讨论应对这些问题的方式，不仅针对乳酸作为单一应激因素的情况，还将讨论其与其他应激因素共同作用的情况。此外，还将讨论使用靶向和非靶向工程方法提高细胞对乳酸耐受性的不同方法。
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2
Effect of Acetic Acid and Lactic Acid at Low pH in Growth and Azole Resistance of and .
Front Microbiol. 2019 Jan 8;9:3265. doi: 10.3389/fmicb.2018.03265. eCollection 2018.
3
Activation of Haa1 and War1 transcription factors by differential binding of weak acid anions in Saccharomyces cerevisiae.
Nucleic Acids Res. 2019 Feb 20;47(3):1211-1224. doi: 10.1093/nar/gky1188.
4
Efficient l-lactic acid production from corncob residue using metabolically engineered thermo-tolerant yeast.
Bioresour Technol. 2019 Feb;273:220-230. doi: 10.1016/j.biortech.2018.11.018. Epub 2018 Nov 7.
5
Low-pH production of d-lactic acid using newly isolated acid tolerant yeast Pichia kudriavzevii NG7.
Biotechnol Bioeng. 2018 Sep;115(9):2232-2242. doi: 10.1002/bit.26745. Epub 2018 Jul 6.
6
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Bioengineering (Basel). 2018 Feb 16;5(1):17. doi: 10.3390/bioengineering5010017.
7
Metabolic engineering of via CRISPR-Cas9 genome editing for lactic acid production from glucose and cellobiose.
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9
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