组学技术在神经毒理学研究中的应用。
The Application of Omics Technologies in the Research of Neurotoxicology.
机构信息
The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China.
Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China.
出版信息
Methods Mol Biol. 2021;2326:143-154. doi: 10.1007/978-1-0716-1514-0_10.
Omics technologies offer unprecedented perspectives for the systematic research of complex organisms. Especially, the comprehensive omics provide powerful tools for exploring extensive perception of the biochemical and/or physiological effects of the cells perturbed by poisons through systemic investigation on the different spatiotemporal expression profiles of transcriptomic expression profiling, expressed proteins and metabolites simultaneously by high-throughput and high-sensitivity technology. Therefore, it has been attracted extensive attention in neurotoxicology. During the recent years, the domain of neurotoxicology has progressively assimilated various emerging omics applications, which mainly include transcriptomics, proteomics, and metabolomics, to investigate the molecular mechanisms and potential molecular biomarkers of phenotypic modifications of organisms subjected to poisons or stress factors.
组学技术为复杂生物的系统研究提供了前所未有的视角。特别是，全面的组学为通过高通量和高灵敏度技术同时系统研究转录组表达谱、表达蛋白和代谢物的不同时空表达谱，探索毒物干扰细胞的广泛生化和/或生理效应提供了强大的工具。因此，它在神经毒理学中引起了广泛关注。近年来，神经毒理学领域逐渐吸收了各种新兴的组学应用，主要包括转录组学、蛋白质组学和代谢组学，以研究生物体受到毒物或应激因素影响时表型变化的分子机制和潜在的分子生物标志物。
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