2%阿米替林和 0.5%氯胺酮联合凝胶治疗难治性红斑性肢痛症疼痛-疼痛控制成功的一例报告。

Combination gel of 2% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain - a case report of pain control success.

机构信息

Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Chronic Pain Unit, Department of Anaesthesiology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

出版信息

Rev Esp Anestesiol Reanim (Engl Ed). 2021 May;68(5):293-296. doi: 10.1016/j.redare.2020.05.023. Epub 2021 May 5.

DOI:10.1016/j.redare.2020.05.023

PMID:34140126

Abstract

Erythromelalgia (EM) is a rare autosomal dominant neuropathy characterized by the combination of severe burning pain and erythematous warm extremities. Chronic pain control is most often unsuccessful and a completely effective therapy is yet to be identified. Recent studies have reported significant improvements in pain management using a combination of amitriptyline and ketamine in a topical formulation. We describe a 1-year follow-up pain control success case of a male patient with EM, proposed for topical use of a 2% Amitriptyline and 0.5% Ketamine gel.

摘要

红斑性肢痛症（erythromelalgia，EM）是一种罕见的常染色体显性遗传性神经病，其特征是严重的灼烧样疼痛和红斑性肢端温热。慢性疼痛控制通常是不成功的，尚未确定完全有效的治疗方法。最近的研究报告称，使用阿米替林和氯胺酮的组合以局部制剂形式治疗疼痛可显著改善。我们描述了一名 EM 男性患者的 1 年随访疼痛控制成功案例，提出使用 2%阿米替林和 0.5%氯胺酮凝胶进行局部治疗。