肿瘤细胞 PD-L1 高表达与预后不良相关，而免疫细胞 PD-L1 高表达则是膀胱癌的一个有利预后因素。
High PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor in urothelial carcinoma.
机构信息
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
出版信息
Future Oncol. 2021 Aug;17(22):2893-2905. doi: 10.2217/fon-2021-0092. Epub 2021 Jun 30.
To explore the prognostic value of high PD-L1 expression on tumor cells (TC) and tumor-infiltrating immune cells (TIIC) in urothelial carcinoma (UC). 162 UC specimens were evaluated for PD-L1 expression on TIIC and TC with the SP263 assay. High PD-L1 expression was defined as ≥25% staining. High PD-L1 expression on TC in UC patients with stage T1-4 disease was associated with poor overall survival. However, high PD-L1 expression on TIIC in UC patients with stage T1-4 disease revealed favorable disease-free and overall survival; more significant differences were observed in patients with stages T2-4. Multivariate analysis revealed that high PD-L1 expression on TIIC was an independent prognostic predictor for better disease-free and overall survival. High PD-L1 expression on TIIC, but not on TC, is a favorable prognostic factor in UC.
探讨肿瘤细胞（TC）和肿瘤浸润免疫细胞（TIIC）中高 PD-L1 表达对膀胱癌（UC）的预后价值。用 SP263 法检测 162 例 UC 标本中 TIIC 和 TC 上的 PD-L1 表达。高 PD-L1 表达定义为≥25%的染色。在 T1-4 期疾病的 UC 患者中，TC 上的高 PD-L1 表达与总生存期差相关。然而，在 T1-4 期疾病的 UC 患者中，TIIC 上的高 PD-L1 表达提示无病生存期和总生存期良好；在 T2-4 期患者中观察到更显著的差异。多变量分析显示，TIIC 上的高 PD-L1 表达是无病生存期和总生存期更好的独立预后预测因子。TIIC 上的高 PD-L1 表达（而非 TC 上）是 UC 的有利预后因素。
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