一种双功能肽缀合物，可控制梨树感染。
A Bifunctional Peptide Conjugate That Controls Infections of in Pear Plants.
机构信息
LIPPSO, Department of Chemistry, Campus Montilivi, University of Girona, 17003 Girona, Spain.
Laboratory of Plant Pathology, Institute of Food and Agricultural Technology-CIDSAV-XaRTA, Campus Montilivi, University of Girona, 17003 Girona, Spain.
出版信息
Molecules. 2021 Jun 5;26(11):3426. doi: 10.3390/molecules26113426.
In this paper, peptide conjugates were designed and synthesized by incorporating the antimicrobial undecapeptide at the C- or N-terminus of the plant defense elicitor peptide , leading to and , respectively. The evaluation of their in vitro activity against six plant pathogenic bacteria revealed that displayed MIC values between 1.6 and 12.5 μM, being more active than , , , and an equimolar mixture of and . Moreover, was neither hemolytic nor toxic to tobacco leaves. triggered the overexpression of 6 out of the 11 plant defense-related genes tested. Interestingly, inhibited infections in pear plants, showing slightly higher efficacy than the mixture of and , and both treatments were as effective as the antibiotic kasugamycin. Thus, the bifunctional peptide conjugate is a promising agent to control fire blight and possibly other plant bacterial diseases.
在本文中，通过在植物防御激发肽的 C 端或 N 端引入抗菌十一肽，设计并合成了肽缀合物，分别得到 和 。对它们体外抗六种植物病原菌活性的评价表明， 对 MIC 值在 1.6-12.5 μM 之间，比 、 、 、和 等摩尔混合物更具活性。此外， 既没有溶血作用，也不对烟草叶片有毒。 触发了 11 个测试的植物防御相关基因中的 6 个过表达。有趣的是， 抑制了梨树上的 感染，其效果略高于 和 的混合物，两种处理方法均与抗生素井冈霉素一样有效。因此，双功能肽缀合物 是一种有前途的防治火疫病的药剂，可能对其他植物细菌性疾病也有效。
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