Department of Preventive Medicine, University of Southern California, Los Angeles, Calif.
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.
J Allergy Clin Immunol. 2021 Jul;148(1):1-14. doi: 10.1016/j.jaci.2021.05.006.
In this narrative review, we summarize the literature and provide updates on recent studies of air pollution exposures and child lung function and lung function growth. We include exposures to outdoor air pollutants that are monitored and regulated through air quality standards, and air pollutants that are not routinely monitored or directly regulated, including wildfires, indoor biomass and coal burning, gas and wood stove use, and volatile organic compounds. Included is a more systematic review of the recent literature on long-term air pollution and child lung function because this is an indicator of future adult respiratory health and exposure assessment tools have improved dramatically in recent years. We present "summary observations" and "knowledge gaps." We end by discussing what is known about what can be done at the individual/household, local/regional, and national levels to overcome structural impediments, reduce air pollution exposures, and improve child lung function. We found a large literature on adverse air pollution effects on children's lung function level and growth; however, many questions remain. Important areas needing further research include whether early-life effects are fixed or reversible; and what are windows of increased susceptibility, long-term effects of repeated wildfire events, and effects of air quality interventions.
在这篇叙述性综述中,我们总结了文献,并提供了最近关于空气污染暴露与儿童肺功能和肺功能发育的研究更新。我们包括了通过空气质量标准监测和监管的室外空气污染物,以及未被常规监测或直接监管的空气污染物,包括野火、室内生物质和煤炭燃烧、燃气和柴火炉使用以及挥发性有机化合物。我们还对最近关于长期空气污染和儿童肺功能的文献进行了更系统的综述,因为这是未来成人呼吸道健康的一个指标,而且近年来暴露评估工具已得到了显著改善。我们提出了“总结性观察”和“知识空白”。最后,我们讨论了在个人/家庭、地方/地区和国家层面上可以采取哪些措施来克服结构性障碍、减少空气污染暴露并改善儿童的肺功能。我们发现了大量关于不良空气污染对儿童肺功能水平和发育影响的文献;然而,仍有许多问题有待解决。需要进一步研究的重要领域包括早期影响是否是固定的或可逆转的;以及易感窗口、反复野火事件的长期影响以及空气质量干预措施的效果。