Center for Reducing Health Disparities, and.
Division of Pulmonary, Critical Care, and Sleep Medicine, The MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio.
Ann Am Thorac Soc. 2022 Feb;19(2):272-278. doi: 10.1513/AnnalsATS.202012-1483OC.
Prior work suggests that Black patients have more severe obstructive sleep apnea (OSA) upon clinical presentation. However, the extent to which this may reflect differences in symptoms or other standard measures of OSA risk is unclear. We assessed for racial disparities in OSA characteristics at time of initial clinical diagnosis. Data from 890 newly diagnosed patients with OSA at an urban academic sleep center were included in this analysis. All patients completed a standardized questionnaire on demographics and sleep-related symptoms and underwent laboratory polysomnography. Symptom severity at the time of evaluation was compared across race and sex. Black men were underrepresented in the sleep lab, making up only 15.8% of the cohort and 31.3% of Black participants ( < 0.001). Despite this, Black men had the most severe OSA with a mean apnea hypopnea index of 52.4 ± 39.4 events/hour, compared with 39.0 ± 28.9 in White men, 33.4 ± 32.3 in Black women, and 26.2 ± 23.8 in White women ( < 0.001 for test of homogeneity). Black men also had the greatest burden of OSA symptoms with the highest mean Epworth Sleepiness Scale score (12.2 ± 5.9 versus 9.4 ± 5.2 in White men, 11.2 ± 5.9, in Black women, and 9.8 ± 5.6 in White women; < 0.001). Compared with White men, Black men were 1.61 (95% CI [1.04-2.51]) times more likely to have witnessed apneas and 1.56 (95% CI [1.00-2.46]) times more likely to have drowsy driving at the time of OSA diagnosis. At the time of clinical diagnosis, Black men have greater disease severity, suggesting delay in diagnosis. Further, the greater burden of classic OSA symptoms suggests the delayed diagnosis of OSA in Black men is not due to atypical presentation. Further research is needed to identify why screening methods for OSA are not equitably implemented in the care of Black men.
先前的研究表明,黑人患者在临床就诊时患有更严重的阻塞性睡眠呼吸暂停(OSA)。然而,这种情况在多大程度上反映了症状或其他 OSA 风险的标准测量指标的差异尚不清楚。我们评估了黑人患者在初次临床诊断时的 OSA 特征是否存在种族差异。这项分析纳入了 890 名在城市学术睡眠中心被诊断为 OSA 的新患者的数据。所有患者都完成了一份关于人口统计学和睡眠相关症状的标准化问卷,并接受了实验室多导睡眠图检查。根据种族和性别比较评估时的症状严重程度。黑人男性在睡眠实验室中的代表性不足,仅占队列的 15.8%和黑人参与者的 31.3%(<0.001)。尽管如此,黑人男性的 OSA 最严重,平均呼吸暂停低通气指数为 52.4±39.4 次/小时,而白人男性为 39.0±28.9 次/小时,黑人女性为 33.4±32.3 次/小时,白人女性为 26.2±23.8 次/小时(组间差异具有统计学意义<0.001)。黑人男性的 OSA 症状负担也最大,Epworth 嗜睡量表评分最高(12.2±5.9 分,而白人男性为 9.4±5.2 分,黑人女性为 11.2±5.9 分,白人女性为 9.8±5.6 分;<0.001)。与白人男性相比,黑人男性更有可能目睹呼吸暂停(比值比[OR]为 1.61,95%可信区间[CI]为 1.04-2.51),更有可能在 OSA 诊断时出现嗜睡驾驶(OR 为 1.56,95% CI 为 1.00-2.46)。在临床诊断时,黑人男性的疾病严重程度更大,表明诊断延迟。此外,更严重的典型 OSA 症状负担表明,黑人男性的 OSA 诊断延迟不是由于非典型表现。需要进一步研究以确定为什么 OSA 的筛查方法在黑人男性的护理中没有得到公平实施。