黄芪多糖增强 BALB/c 小鼠对 OVA 抗原的免疫应答。
Astragalus Polysaccharides Enhance the Immune Response to OVA Antigen in BALB/c Mice.
机构信息
National Institute of TCM Constitution and Preventive Medicine, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Department of Cancer Prevention, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.
出版信息
Biomed Res Int. 2021 Jun 28;2021:9976079. doi: 10.1155/2021/9976079. eCollection 2021.
Vaccination has been identified as one of the most effective ways to prevent the transmission of infectious diseases in humans and animals. One of the most critical steps in vaccine development is the selection of a suitable adjuvant. Although various adjuvant candidates have been evaluated in the past few decades, only a limited amount of them are nontoxic and safe for human use. Astragalus polysaccharide (APS), due to its lack of toxicity, has been used as an immunomodulator to enhance immune responses. On the other hand, the immune effects of APS on ovalbumin are yet to be examined. Thus, in this study, we analyzed APS's effects on the immune response to ovalbumin in BALB/c mice. We have also used the classic adjuvant CpG oligodeoxynucleotide as the positive control.
疫苗接种已被确定为预防人类和动物传染病传播的最有效方法之一。疫苗开发中最关键的步骤之一是选择合适的佐剂。尽管在过去几十年中已经评估了各种佐剂候选物，但只有有限数量的佐剂对人体是无毒且安全的。黄芪多糖（APS）由于其无毒，已被用作免疫调节剂来增强免疫反应。另一方面，APS 对卵清蛋白的免疫作用尚未被检测。因此，在这项研究中，我们分析了 APS 对 BALB/c 小鼠卵清蛋白免疫反应的影响。我们还使用经典佐剂 CpG 寡脱氧核苷酸作为阳性对照。
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