先天免疫——小儿慢性胃炎感染的标志。
Innate immunity - the hallmark of infection in pediatric chronic gastritis.
作者信息
Meliț Lorena Elena, Mărginean Cristina Oana, Săsăran Maria Oana, Mocan Simona, Ghiga Dana Valentina, Bogliş Alina, Duicu Carmen
机构信息
Department of Pediatrics I, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Târgu Mureș 540136, Romania.
Department of Pediatrics III, "George Emil Palade" University of Medicine, Pharmacy, Sciences and Technology Târgu Mureș, Târgu Mureș 540136, Romania.
出版信息
World J Clin Cases. 2021 Aug 16;9(23):6686-6697. doi: 10.12998/wjcc.v9.i23.6686.
BACKGROUND
Innate immunity was found to be associated with both persistence of infection and increased risk of gastric cancer.
AIM
To identify the risk factors associated with infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.
METHODS
We performed a study of 155 children with digestive symptoms, who were divided into two groups according to the histopathological exam: Group 1 - 48 children with -induced chronic gastritis, and Group 2 - control group.
RESULTS
Rural area and poor living conditions were significantly associated with chronic gastritis ( = 0.0042/ < 0.0001). Both positive immunoglobulin A anti and the rapid urease test were significantly associated with infection ( < 0.0001). Significantly higher values of leukocytes and neutrophils within the peripheral blood were found in children with chronic gastritis ( = 0.111/ = 0.284). We found a significant positive correlation between the variant TT genotype of TLR9 rs352140 polymorphism and both leucocytes and neutrophils ( = 0.0225/ = 0.0292).
CONCLUSION
Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation.
背景
发现固有免疫与感染的持续存在以及胃癌风险增加相关。
目的
确定与感染相关的危险因素，并确立TLR9 rs352140在抑制或促进儿童与该感染相关炎症中的作用。
方法
我们对155名有消化症状的儿童进行了一项研究，根据组织病理学检查将他们分为两组：第1组 - 48名患有幽门螺杆菌诱导的慢性胃炎的儿童，第2组 - 对照组。
结果
农村地区和生活条件差与幽门螺杆菌慢性胃炎显著相关（P = 0.0042/P < 0.0001）。免疫球蛋白A抗幽门螺杆菌阳性和快速尿素酶试验均与幽门螺杆菌感染显著相关（P < 0.0001）。幽门螺杆菌慢性胃炎患儿外周血白细胞和中性粒细胞值显著更高（P = 0.111/P = 0.284）。我们发现TLR9 rs352140多态性的变异TT基因型与白细胞和中性粒细胞之间存在显著正相关（P = 0.0225/P = 0.0292）。
结论
TLR9 rs352140基因多态性的变异TT基因型携带者可能有更严重程度的炎症。
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