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严重急性呼吸综合征冠状病毒2型单克隆抗体治疗后住院情况作为纽约市病毒变体出现的哨兵监测指标

Post-severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Treatment Hospitalizations as a Sentinel for Emergence of Viral Variants in New York City.

作者信息

Cowman Kelsie, Guo Yi, Pirofski Liise-Anne, Wong David, Bao Hongkai, Chen Victor, Hopkins Una, Andrews Erin, Hamel Joseph, Keller Marla, Bellin Eran, Thota Raja, Davis Patricia, Rodriguez Edwin Torres, Suthar Pooja, Allen Lauren, Rossi James, Haviland Adam, Orner Erika, Szymczak Wendy, Shujauddin Sadahf, McCarthy James, Binder Barbara, Pushparaj Vanitha, Bard Linda, Pierino Vincent Frank, Alsina Leslie, Esses David, McCaskie Alicia, Campbell Caron, Madzura Tabitha, Wollowitz Andrew, Basset Kelly, White Deborah, Ruiz Rafael, Sosnowski Frank, Nori Priya

机构信息

Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.

Department of Pharmacy, Montefiore Medical Center, Bronx, New York, USA.

出版信息

Open Forum Infect Dis. 2021 Jun 12;8(8):ofab313. doi: 10.1093/ofid/ofab313. eCollection 2021 Aug.

Abstract

We partnered with the US Department of Health and Human Services to treat high-risk, nonadmitted coronavirus disease 2019 (COVID-19) patients with bamlanivimab in the Bronx, New York per Emergency Use Authorization criteria. Increasing posttreatment hospitalizations were observed monthly between December 2020 and March 2021 in parallel to the emergence of severe acute respiratory syndrome coronavirus 2 variants in New York City.

摘要

我们与美国卫生与公众服务部合作,根据紧急使用授权标准,在纽约布朗克斯区使用巴瑞替尼治疗高危、未入院的2019冠状病毒病(COVID-19)患者。2020年12月至2021年3月期间,每月都观察到治疗后住院人数增加,这与纽约市出现严重急性呼吸综合征冠状病毒2变种的情况同时发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e5/8391090/d6b9b81c2aa1/ofab313_iffig1.jpg

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