School of Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Department of Dermatology, MD Anderson Cancer Center, Houston, TX, USA.
Am J Clin Dermatol. 2022 Jan;23(1):37-50. doi: 10.1007/s40257-021-00636-1. Epub 2021 Sep 8.
Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged that further elucidates GA epidemiology and etiopathogenesis; importantly, new therapeutic options for GA have also been described, although there remains a paucity of randomized controlled studies. In this review, we summarize recent updates on GA epidemiology and etiopathogenesis and offer an updated review of the therapeutic options for GA currently reported in the literature. We hope that the current review galvanizes randomized controlled studies that will in turn help lead to the recommendation of evidence-based treatments for GA.
环状肉芽肿(GA)是一种炎症性肉芽肿性皮肤病,可分为局限性(局限性 GA)或播散性(全身性 GA),斑片状、穿孔状和皮下亚型是这种良性疾病较为少见的变异型。最近,新的研究进一步阐明了 GA 的流行病学和发病机制;重要的是,也描述了 GA 的新治疗选择,尽管针对 GA 的随机对照研究仍然很少。在这篇综述中,我们总结了 GA 的流行病学和发病机制的最新进展,并对目前文献中报道的 GA 的治疗选择进行了更新。我们希望本综述能激发更多的随机对照研究,从而有助于推荐 GA 的循证治疗方法。