从苯二氮䓬类药物到脂肪酸类药物，以及更多：重新探讨 ACBP/DBI 的作用。
From benzodiazepines to fatty acids and beyond: revisiting the role of ACBP/DBI.
机构信息
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal Diabetes Research Center, and Departments of Medicine, Pharmacology and Physiology, Biochemistry, and Neurosciences, Université de Montréal, Montreal, QC, Canada.
Department of Molecular and Integrative Physiology, Neuroscience Program, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
出版信息
Trends Endocrinol Metab. 2021 Nov;32(11):890-903. doi: 10.1016/j.tem.2021.08.009. Epub 2021 Sep 23.
Four decades ago Costa and colleagues identified a small, secreted polypeptide in the brain that can displace the benzodiazepine diazepam from the GABA receptor, and was thus termed diazepam binding inhibitor (DBI). Shortly after, an identical polypeptide was identified in liver by its ability to induce termination of fatty acid synthesis, and was named acyl-CoA binding protein (ACBP). Since then, ACBP/DBI has been studied in parallel without a clear and integrated understanding of its dual roles. The first genetic loss-of-function models have revived the field, allowing targeted approaches to better understand the physiological roles of ACBP/DBI in vivo. We discuss the roles of ACBP/DBI in central and tissue-specific functions in mammals, with an emphasis on metabolism and mechanisms of action.
四十年前，Costa 及其同事在大脑中发现了一种小的分泌型多肽，它可以将苯二氮䓬类药物地西泮从 GABA 受体上置换下来，因此被命名为地西泮结合抑制剂（Diazepam Binding Inhibitor，DBI）。不久之后，由于其能够诱导脂肪酸合成终止的能力，在肝脏中发现了一种相同的多肽，并被命名为酰基辅酶 A 结合蛋白（acyl-CoA Binding Protein，ACBP）。此后，ACBP/DBI 一直被平行研究，但对其双重作用缺乏清晰和综合的理解。第一个遗传功能丧失模型使该领域重获生机，允许采用靶向方法更好地理解 ACBP/DBI 在体内的生理作用。我们讨论了 ACBP/DBI 在哺乳动物中枢和组织特异性功能中的作用，重点讨论了代谢和作用机制。
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