饮食-宿主-微生物群相互作用塑造芳香烃受体配体的产生，以调节肠道内稳态。
Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis.
机构信息
Program in Integrative Nutrition and Complex Diseases and Department of Nutrition, Texas A&M University, College Station, Texas 77843, USA; email:
Department of Biochemistry & Biophysics, Texas A&M University, College Station, Texas 77843, USA.
出版信息
Annu Rev Nutr. 2021 Oct 11;41:455-478. doi: 10.1146/annurev-nutr-043020-090050.
The aryl hydrocarbon receptor (AhR) is a ligand-activated basic-helix-loop-helix transcription factor that binds structurally diverse ligands and senses cues from environmental toxicants and physiologically relevant dietary/microbiota-derived ligands. The AhR is an ancient conserved protein and is widely expressed across different tissues in vertebrates and invertebrates. AhR signaling mediates a wide range of cellular functions in a ligand-, cell type-, species-, and context-specific manner. Dysregulation of AhR signaling is linked to many developmental defects and chronic diseases. In this review, we discuss the emerging role of AhR signaling in mediating bidirectional host-microbiome interactions. We also consider evidence showing the potential for the dietary/microbial enhancement ofhealth-promoting AhR ligands to improve clinical pathway management in the context of inflammatory bowel diseases and colon tumorigenesis.
芳香烃受体 (AhR) 是一种配体激活的碱性螺旋-环-螺旋转录因子，可结合结构多样的配体，并感知环境毒物和生理相关的膳食/微生物衍生配体发出的信号。AhR 是一种古老的保守蛋白，在脊椎动物和无脊椎动物的不同组织中广泛表达。AhR 信号以配体、细胞类型、物种和特定环境的方式介导广泛的细胞功能。AhR 信号的失调与许多发育缺陷和慢性疾病有关。在这篇综述中，我们讨论了 AhR 信号在介导宿主-微生物组双向相互作用中的新作用。我们还考虑了证据表明，膳食/微生物增强促进健康的 AhR 配体有可能改善炎症性肠病和结肠肿瘤发生情况下的临床途径管理。
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