Severe impairment of T-cell responses to BNT162b2 immunization in patients with multiple myeloma.

作者信息

Enßle Julius C, Campe Julia, Schwenger Amelie, Wiercinska Eliza, Hellstern Helen, Dürrwald Ralf, Rieger Michael A, Wolf Sebastian, Ballo Olivier, Steffen Björn, Serve Hubert, Bonig Halvard, Rabenau Holger F, Widera Marek, Ciesek Sandra, Metzler Ivana von, Ullrich Evelyn

机构信息

Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.

出版信息

Blood. 2022 Jan 6;139(1):137-142. doi: 10.1182/blood.2021013429.

DOI:10.1182/blood.2021013429

PMID:34657156

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8734828/

Abstract

摘要

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Blood Cancer Discov. 2020 Nov 4;1(3):290. doi: 10.1158/2643-3230.BCD-20-0160. eCollection 2020 Nov.

COVID-19 in multiple-myeloma patients: cellular and humoral immunity against SARS-CoV-2 in a short- and long-term view.

J Mol Med (Berl). 2022 Mar;100(3):463-470. doi: 10.1007/s00109-021-02114-x. Epub 2021 Oct 18.

Current perspectives for SARS-CoV-2 vaccination efficacy improvement in patients with active treatment against cancer.

Eur J Cancer. 2021 Sep;154:66-72. doi: 10.1016/j.ejca.2021.06.008. Epub 2021 Jun 18.

Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma.

Cancer Cell. 2021 Aug 9;39(8):1028-1030. doi: 10.1016/j.ccell.2021.06.014. Epub 2021 Jun 29.

Immunogenicity of the BNT162b2 COVID-19 mRNA vaccine and early clinical outcomes in patients with haematological malignancies in Lithuania: a national prospective cohort study.

Lancet Haematol. 2021 Aug;8(8):e583-e592. doi: 10.1016/S2352-3026(21)00169-1. Epub 2021 Jul 2.

Seroconversion rates following COVID-19 vaccination among patients with cancer.

Cancer Cell. 2021 Aug 9;39(8):1081-1090.e2. doi: 10.1016/j.ccell.2021.06.002. Epub 2021 Jun 5.

Utility of Different Surrogate Enzyme-Linked Immunosorbent Assays (sELISAs) for Detection of SARS-CoV-2 Neutralizing Antibodies.

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