Evaluation of Essential Oil on Anti- Activity.

The current methods of treating toxoplasmosis have a number of side effects, and these therapies are only effective against the acute stage of the disease. Thus, development of new low toxicity and efficient anti- drugs is extremely important. Natural products are important sources for screening new drugs; among them, essential oils (EOs) have efficacy in anti-bacterial, anti-inflammatory, anti-insect, and other aspects. In this study, 16 EOs were screened for their anti- activity. essential oil ( EO)was found to have an anti-parasitic effect on . The cytotoxicity of EO was firstly evaluated using the MTT assay on human foreskin fibroblast (HFF) cells, and then the anti- activity was evaluated by plaque assay. Finally, the invasion experiment and electron microscope observation were used to study the mechanism of EO in anti-toxoplasma activity. The results indicated that the CC of EO was 4.48 mg/ml and that EO had activity against and the inhibition was in a dose-dependent manner under safe concentrations. EO was able to reduce invasion, which may be due to its detrimental effect on changes of the morphology of tachyzoites. These findings indicated that EO could be a potential drug for treating toxoplasmosis.