鉴定能延长酵母时序寿命的热带植物提取物。

Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span.

机构信息

Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia-USM, Penang 11800, Malaysia.

USM-RIKEN International Centre for Ageing Science (URICAS), Universiti Sains Malaysia-USM, Penang 11800, Malaysia.

出版信息

Cells. 2021 Oct 11;10(10):2718. doi: 10.3390/cells10102718.

DOI:10.3390/cells10102718

PMID:34685698

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8534465/

Abstract

Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of and that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways.

摘要

某些植物提取物 (PEs) 含有具有抗氧化和延长生物体寿命活性的生物活性化合物。这些 PEs 在细胞过程中发挥不同的作用，例如增强应激抗性和调节与寿命相关的信号通路，从而有助于延长寿命。在这里，我们报告了从 222 种 PEs 的筛选中发现的能够延长出芽酵母的时序寿命 (CLS) 的 PEs。我们鉴定出两种 PEs，和的叶提取物以剂量依赖的方式延长 CLS。延长 CLS 的 PEs 还赋予了氧化应激耐受性，这表明这些 PEs 可能通过上调应激反应途径来延长酵母 CLS。