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自噬与感染

Autophagy in Infection.

机构信息

Beijing Key Laboratory of Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, China.

National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.

出版信息

Front Cell Infect Microbiol. 2021 Oct 7;11:750222. doi: 10.3389/fcimb.2021.750222. eCollection 2021.

Abstract

is an invasive, facultative intracellular pathogen that can colonize niches in various host organisms, making it difficult for the host immune system to completely eliminate. Host autophagy is an intracellular clearance pathway involved in degrading . Whereas the accessory gene regulatory system of that controls virulence factors could resist the host immune defenses by evading and even utilizing autophagy. This article reviews the interaction between autophagy and , providing insights on how to use these mechanisms to improve infection control.

摘要

是一种侵袭性、兼性细胞内病原体,能够定殖于各种宿主生物的小生境,使宿主免疫系统难以完全清除。宿主自噬是一种参与降解 的细胞内清除途径。而控制毒力因子的 辅助基因调控系统可以通过逃避甚至利用自噬来抵抗宿主的免疫防御。本文综述了自噬与 的相互作用,为利用这些机制改善 感染控制提供了思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7bf/8529010/0acd35569fd3/fcimb-11-750222-g001.jpg

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