用于 RNA 递送的可离子化脂质工具包。
An ionizable lipid toolbox for RNA delivery.
机构信息
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Laboratory of Biophysics, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Abrahama 58, 80-307, Gdańsk, Poland.
出版信息
Nat Commun. 2021 Dec 13;12(1):7233. doi: 10.1038/s41467-021-27493-0.
Abstract
Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component—the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.
摘要
近年来，RNA 疗法取得了令人瞩目的发展，这得益于几十年来对脂质纳米颗粒的研究，特别是其关键组成部分——可离子化脂质。本文讨论了主要的可离子化脂质类型，并对未来的发展提供了一些观点。
Zotero 插件