Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn and its Applications in Cell Imaging and Detection of Cu.

A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to different metal ions (Mn, Ca, Fe, Fe, Mg, Al, Ba, Ag, Co, Na, K, Cu, Zn, Pb, Bi) were studied by absorption and fluorescence titration. The results show that FPS has selective fluorescence sensing behavior for Zn ions and the limit of detection (LOD) was calculated to be 1.19 × 10 mol/L. Moreover, FPS-Zn acts as a metal based highly selective and sensitive new chemosensor for Cu ions and the LOD was calculated to be 2.25 × 10 mol/L. In accordance with the results and theoretical calculations, we suspected that the binding mechanisms of FPS to Zn and Cu were assigned to be the cooperative interaction of Zn(Cu)-N.