Determination of the pharmaceuticals-nano/microplastics in aquatic systems by analytical and instrumental methods.

Pharmaceutical residues and nanoplastic and microplastic particles as emerging pollutants in the aquatic environment are a subject of increasing concern in terms of the effect on water sources and marine organisms. There is lack of information about pharmaceutical-nanoplastic and pharmaceutical-microplastic mixtures. The present study aimed to investigate the fate and effect of pharmaceutical residues and nanoplastic and microplastic particles, the results of combinations of pharmaceutical residues with nanoplastic and microplastic particles, and toxic effects of pharmaceutical residues and nanoplastic and microplastic particles. Moreover, the objective was also to introduce analytical methods for pharmaceuticals, along with instrumental techniques for nanoplastic and microplastic particles in aquatic environments and organisms. PhAC alone can affect marine environments and aquatic organisms. When pharmaceutical residues combine with nanoplastic and microplastic particles, the rate of toxicity increases, and the result of this phenomenon constitutes this kind of pollutant in wastewater. Hence, the rate of mortality in organisms enhances. This study aimed to investigate the effect of pharmaceuticals residues and nanoplastic and microplastic particles, and a mixture of pharmaceutical residues and nanoplastic and microplastic particles in aquatic biota. Another object was survey methods for recognizing pharmaceutical residues and nanoplastic and microplastic particles. The findings show that pharmaceutical residues in organisms caused cell structure damage, inflammatory response, and nerve cell apoptosis. This study aimed to investigate the effect of microplastic particles in the human food chain and their impact on human health. Moreover, this review aims to present an innovative methodology based on comprehensive analytical techniques used to determine and identify pharmaceuticals adsorbed on nano- and microplastics in aquatic ecosystems. Finally, this review addresses the knowledge gaps and provides insights into future research strategies to better understand their interactions.