严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变异株奥密克戎：目前最彻底的抗体和疫苗中和“逃逸者” 。 - Suppr

SARS-CoV-2 variant Omicron: currently the most complete "escapee" from neutralization by antibodies and vaccines.

作者信息

Li Maochen, Lou Fuxing, Fan Huahao

机构信息

College of Life Science and Technology, Beijing University of Chemical Technology, 100029, Beijing, China.

出版信息

Signal Transduct Target Ther. 2022 Jan 28;7(1):28. doi: 10.1038/s41392-022-00880-9.

DOI:10.1038/s41392-022-00880-9

PMID:35091532

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8795721/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b8c/8799709/a551743cd278/41392_2022_880_Fig1_HTML.jpg

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Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2.

Nature. 2022 Feb;602(7898):676-681. doi: 10.1038/s41586-021-04388-0. Epub 2021 Dec 23.

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.

Nature. 2022 Feb;602(7898):654-656. doi: 10.1038/s41586-021-04387-1. Epub 2021 Dec 23.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift.

Nature. 2022 Feb;602(7898):664-670. doi: 10.1038/s41586-021-04386-2. Epub 2021 Dec 23.

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies.

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Lancet Microbe. 2022 Feb;3(2):e91. doi: 10.1016/S2666-5247(21)00278-0. Epub 2021 Nov 25.

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SARS-CoV-2 variant Omicron: currently the most complete "escapee" from neutralization by antibodies and vaccines.

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