一种芘基-吡啶纳米寡聚物作为一种甲氧基触发的反应探针，用于次氯酸盐的高特异性荧光分析。
A pyrene-pyridyl nanooligomer as a methoxy-triggered reactive probe for highly specific fluorescence assaying of hypochlorite.
机构信息
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, P. R. China.
出版信息
Chem Commun (Camb). 2022 Feb 17;58(15):2520-2523. doi: 10.1039/d1cc06606d.
A novel pyrene-pyridyl conjugated oligomer (OPP-OMe) was conveniently prepared by one-pot Sonogashira coupling. Intriguingly, it was found that introducing only one methoxy moiety at the 4-pyridyl position can be sufficient for creating an oligomer-based ultrafine reactive fluorescent nanoprobe, , OPP-OMe NPs ( 2.5 nm in diameter). Spectral analyses and elucidation of the intermediate structure revealed that the methoxy triggered-oxidation, together with nanoaggregation of OPP-OMe NPs, results in rapid, specific and supersensitive sensing of hypochlorite (LOD, 0.3 nM, S/N = 3).
一种新型的芘-吡啶共轭低聚物（OPP-OMe）可通过一锅 Sonogashira 偶联法方便地制备。有趣的是，人们发现只需在 4-吡啶位置引入一个甲氧基，就足以构建基于低聚物的超精细反应性荧光纳米探针，即 OPP-OMe NPs（直径 2.5nm）。光谱分析和中间结构的阐明表明，甲氧基引发的氧化以及 OPP-OMe NPs 的纳米聚集导致次氯酸盐的快速、特异性和超灵敏检测（LOD，0.3nM，S/N=3）。
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