肠道微生物群与昼夜节律之间的重要联系：对昼夜节律性睡眠障碍治疗的启示
An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder.
作者信息
Tian Yufei, Yang Wei, Chen Gang, Men Chuanlong, Gu Yifan, Song Xiaoran, Zhang Ruilin, Wang Laiyou, Zhang Xin
机构信息
Department of Food Science and Engineering, Ningbo University, 818 Fenghua Road, Ningbo, 315211 People's Republic of China.
Department of Clinical Pharmacy, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080 Guangdong People's Republic of China.
出版信息
Food Sci Biotechnol. 2022 Jan 18;31(2):155-164. doi: 10.1007/s10068-021-01015-6. eCollection 2022 Feb.
Currently, gut microbiota living in the gastrointestinal tract, plays an important role in regulating host's sleep and circadian rhythms. As a tool, gut microbiota has great potential for treating circadian disturbance and circadian insomnia. However, the relationship between gut microbiota and circadian rhythms is still unclear, and the mechanism of action has still been the focus of microbiome research. Therefore, this article summarizes the current evidences associating gut microbiota with factors that impact host circadian rhythms neurology sleep disorder. Moreover, we discuss the changes to these systems in sleep disorder and the potential mechanism of intestinal microbiota in regulating circadian rhythms neurology sleep disorder via microbial metabolites. Meanwhile, based on the role of intestinal flora, it is provided a novel insight into circadian related insomnia and will be benefit the dietary treatment of circadian disturbance and the circadian related insomnia.
目前，生活在胃肠道中的肠道微生物群在调节宿主睡眠和昼夜节律方面发挥着重要作用。作为一种工具，肠道微生物群在治疗昼夜节律紊乱和昼夜节律性失眠方面具有巨大潜力。然而，肠道微生物群与昼夜节律之间的关系仍不清楚，其作用机制仍是微生物组研究的重点。因此，本文总结了目前将肠道微生物群与影响宿主昼夜节律神经学睡眠障碍的因素相关联的证据。此外，我们讨论了睡眠障碍中这些系统的变化以及肠道微生物群通过微生物代谢产物调节昼夜节律神经学睡眠障碍的潜在机制。同时，基于肠道菌群的作用，为昼夜节律相关失眠提供了新的见解，并将有利于昼夜节律紊乱和昼夜节律相关失眠的饮食治疗。
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