香芹酚和丁香酚壳聚糖纳米颗粒作为化妆品中环保防腐剂的比较评价
Comparative evaluation of carvacrol and eugenol chitosan nanoparticles as eco-friendly preservative agents in cosmetics.
作者信息
Mondéjar-López Maria, López-Jimenez Alberto José, García Martínez Joaquin C, Ahrazem Oussama, Gómez-Gómez Lourdes, Niza Enrique
机构信息
Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Escuela Técnica Superior de Ingenieros Agrónomos y Montes, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
出版信息
Int J Biol Macromol. 2022 May 1;206:288-297. doi: 10.1016/j.ijbiomac.2022.02.164. Epub 2022 Feb 28.
The current status of controversy regarding the use of certain preservatives in cosmetic products makes it necessary to seek new ecological alternatives that are free of adverse effects on users. In our study, two different natural terpenes Carvacrol and Eugenol were encapsulated in chitosan nanoparticles in different ratios of Chitosan:terpene. The nanoparticles were characterized by DLS and TEM showing a maximum particle size of 100 nm. The chemical structure, thermal properties, and release profile of terpenes were evaluated showing a successful protection of terpene in Chitosan matrix. Two different release profile were observed showing a faster release profile in the case of Eugenol. Antimicrobial properties of nanoparticles were evaluated against typical microbial contaminants found in cosmetic products, showing higher antimicrobial properties with chitosan encapsulation of terpenes. Furthermore, natural moisturizing cream inoculated with beforementioned microorganisms was formulated with Carvacrol-chitosan nanoparticles and Eugenol-chitosan nanoparticles to evaluate the preservative efficiency, indicating a highest preservative efficiency with the use of Eugenol-chitosan nanoparticles.
目前关于化妆品中某些防腐剂使用的争议现状使得有必要寻找对使用者无不良影响的新型生态替代品。在我们的研究中，两种不同的天然萜类化合物香芹酚和丁香酚以不同的壳聚糖：萜类比例被包裹在壳聚糖纳米颗粒中。通过动态光散射（DLS）和透射电子显微镜（TEM）对纳米颗粒进行表征，结果显示最大粒径为100纳米。对萜类化合物的化学结构、热性能和释放曲线进行了评估，结果表明萜类在壳聚糖基质中得到了成功保护。观察到两种不同的释放曲线，丁香酚的释放曲线更快。对纳米颗粒针对化妆品中常见的典型微生物污染物的抗菌性能进行了评估，结果显示萜类化合物经壳聚糖包裹后具有更高的抗菌性能。此外，用香芹酚 - 壳聚糖纳米颗粒和丁香酚 - 壳聚糖纳米颗粒配制接种了上述微生物的天然保湿霜，以评估其防腐效率，结果表明使用丁香酚 - 壳聚糖纳米颗粒时防腐效率最高。
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