用于治疗传染性肺病的肺部递药策略路线图。
A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
出版信息
J Nanobiotechnology. 2022 Mar 3;20(1):101. doi: 10.1186/s12951-022-01307-x.
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view.
肺部给药是治疗肺部传染病的一个极具吸引力的课题。肺部给药具有无首过效应和高生物利用度的独特优势，为将治疗剂直接递送到肺部病变部位提供了重要手段。本文从肺部的结构特点和实现高效传递的生物屏障出发，旨在对过去十年中用于治疗肺部传染病的肺部传递策略的文献进行综述。希望本文能从传递角度为肺部传染病治疗策略的未来发展提供新的见解。
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