2021 年 11 月 29 日至 2022 年 1 月 2 日丹麦 SARS-CoV-2 变异株奥密克戎 BA.2 亚谱系的分子流行病学。
Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022.
机构信息
Virus Research and Development Laboratory, Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark.
Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
出版信息
Euro Surveill. 2022 Mar;27(10). doi: 10.2807/1560-7917.ES.2022.27.10.2200181.
Following emergence of the SARS-CoV-2 variant Omicron in November 2021, the dominant BA.1 sub-lineage was replaced by the BA.2 sub-lineage in Denmark. We analysed the first 2,623 BA.2 cases from 29 November 2021 to 2 January 2022. No epidemiological or clinical differences were found between individuals infected with BA.1 versus BA.2. Phylogenetic analyses showed a geographic east-to-west transmission of BA.2 from the Capital Region with clusters expanding after the Christmas holidays. Mutational analysis shows distinct differences between BA.1 and BA.2.
2021 年 11 月，SARS-CoV-2 变异株奥密克戎出现后，丹麦的主导 BA.1 亚谱系被 BA.2 亚谱系取代。我们分析了 2021 年 11 月 29 日至 2022 年 1 月 2 日的前 2623 例 BA.2 病例。感染 BA.1 与 BA.2 的个体之间未发现流行病学或临床差异。系统发育分析显示，BA.2 从首都地区向东向西传播，圣诞假期后集群扩大。突变分析显示 BA.1 和 BA.2 之间存在明显差异。
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