氧化还原中性锰催化合成1-吡咯啉。
Redox-neutral manganese-catalyzed synthesis of 1-pyrrolines.
作者信息
Feng Tingting, Liu Canxiang, Wu Zhen, Wu Xinxin, Zhu Chen
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 People's Republic of China
Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 People's Republic of China.
出版信息
Chem Sci. 2022 Feb 9;13(9):2669-2673. doi: 10.1039/d2sc00015f. eCollection 2022 Mar 2.
This report describes a manganese-catalyzed radical [3 + 2] cyclization of cyclopropanols and oxime ethers, leading to valuable multi-functional 1-pyrrolines. In this redox-neutral process, the oxime ethers function as internal oxidants and H-donors. The reaction involves sequential rupture of C-C, C-H and N-O bonds and proceeds under mild conditions. This intermolecular protocol provides an efficient approach for the synthesis of structurally diverse 1-pyrrolines.
本报告描述了一种锰催化的环丙醇与肟醚的自由基[3 + 2]环化反应，生成有价值的多功能1-吡咯啉。在这个氧化还原中性过程中，肟醚充当内氧化剂和氢供体。该反应涉及C-C、C-H和N-O键的顺序断裂，且在温和条件下进行。这种分子间反应方案为合成结构多样的1-吡咯啉提供了一种有效方法。
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