辛巴达：STAT 抑制剂的结构、实验和临床特征及其潜在应用。
SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications.
机构信息
Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland.
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
出版信息
Sci Data. 2022 Mar 31;9(1):139. doi: 10.1038/s41597-022-01243-3.
The abnormal activation of signal transducer and activator of transcription (STAT) protein family is recognized as cause or driving force behind multiple diseases progression. Therefore, searching for potential treatment strategy is pursued by multiple scientific groups. We consider that providing comprehensive, integrated and unified dataset for STAT inhibitory compounds may serve as important tool for other researchers. We developed SINBAD (STAT INhbitor Biology And Drug-ability) in response to our experience with inhibitory compound research, knowing that gathering detailed information is crucial for effective experiment design and also for finding potential solutions in case of obtaining inconclusive results. SINBAD is a curated database of STAT inhibitors which have been published and described in scientific articles providing prove of their inhibitory properties. It is a tool allowing easy analysis of experimental conditions and provides detailed information about known STAT inhibitory compounds.
信号转导子和转录激活子（STAT）蛋白家族的异常激活被认为是多种疾病进展的原因或驱动力。因此，多个科学小组正在寻找潜在的治疗策略。我们认为，为 STAT 抑制化合物提供全面、综合和统一的数据集可能是其他研究人员的重要工具。我们开发了 SINBAD（STAT 抑制剂生物学和药物能力），以应对我们在抑制化合物研究方面的经验，因为我们知道收集详细信息对于有效的实验设计至关重要，而且在获得不确定结果的情况下，也有助于寻找潜在的解决方案。SINBAD 是一个经过精心整理的 STAT 抑制剂数据库，这些抑制剂已在科学文章中发表并描述过，提供了其抑制特性的证据。它是一个允许轻松分析实验条件的工具，并提供有关已知 STAT 抑制化合物的详细信息。
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