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挪威50岁及以上人群非侵袭性肺炎球菌肺炎住院发病率的估计。

Estimation of the incidence of hospitalization for non-invasive pneumococcal pneumonia in the Norwegian population aged 50 years and older.

作者信息

Lyngstad Trude Marie, Kristoffersen Anja Bråthen, Winje Brita Askeland, Steens Anneke

机构信息

Norwegian Institute of Public Health, Oslo, Norway.

European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.

出版信息

Epidemiol Infect. 2022 Apr 4;150:1-21. doi: 10.1017/S0950268822000607.

Abstract

The purpose of this study was to estimate simple measures of the burden of non-invasive pneumococcal pneumonia (PnPn) hospitalisations in those aged 50 years and older (50+) in Norway. We conducted a retrospective register-based study and used discharge codes from the Norwegian Patient Register (NPR). We identified episodes of non-invasive PnPn in 2015 to 2016 and predicted its incidence from 2015 to 2019 based on the trend found in notified invasive pneumococcal disease cases. Overall, we identified 45–46 hospital episodes per 100 000 population of non-invasive PnPn in 2015 and 2016, each episode taking 6–8 days, and with increasing incidence with higher age. Among all identified PnPn episodes, 3 out of 4 were classified as non-invasive. We predicted that the monthly number of non-invasive PnPn episodes ranges from 39 [95% confidence interval (CI) 24–55] in August to 97 (95% CI 74–134) in December. No annual trend was identified. This study indicates that the burden of non-invasive PnPn hospitalisation has a substantial impact on the health and health care use of the 50+ population in Norway, despite the childhood immunisation programme. Many hospitalisations may be prevented through vaccination.

摘要

本研究的目的是评估挪威50岁及以上(50+)人群非侵袭性肺炎球菌肺炎(PnPn)住院负担的简单指标。我们开展了一项基于登记册的回顾性研究,并使用了挪威患者登记册(NPR)中的出院编码。我们确定了2015年至2016年非侵袭性PnPn的发病情况,并根据报告的侵袭性肺炎球菌病病例的趋势预测了2015年至2019年的发病率。总体而言,我们在2015年和2016年每10万人口中确定了45 - 46例非侵袭性PnPn住院病例,每例住院时间为6 - 8天,且发病率随年龄增长而增加。在所有确定的PnPn病例中,四分之三被归类为非侵袭性。我们预测,非侵袭性PnPn病例的月度数量从8月的39例[95%置信区间(CI)24 - 55]到12月的97例(95% CI 74 - 134)不等。未发现年度趋势。这项研究表明,尽管有儿童免疫计划,但非侵袭性PnPn住院负担对挪威50+人群的健康和医疗保健使用仍有重大影响。许多住院病例可通过接种疫苗预防。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a6b6/9044527/4369ba1716b2/S0950268822000607_fig1.jpg

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