用于深部脑刺激和镇痛应用的压电超声能量收集装置。
Piezoelectric ultrasound energy-harvesting device for deep brain stimulation and analgesia applications.
作者信息
Zhang Tao, Liang Huageng, Wang Zhen, Qiu Chaorui, Peng Yuan Bo, Zhu Xinyu, Li Jiapu, Ge Xu, Xu Jianbo, Huang Xian, Tong Junwei, Ou-Yang Jun, Yang Xiaofei, Li Fei, Zhu Benpeng
机构信息
School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China.
Department of Urology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
出版信息
Sci Adv. 2022 Apr 15;8(15):eabk0159. doi: 10.1126/sciadv.abk0159.
Supplying wireless power is a challenging technical problem of great importance for implantable biomedical devices. Here, we introduce a novel implantable piezoelectric ultrasound energy-harvesting device based on Sm-doped Pb(MgNb)O-PbTiO (Sm-PMN-PT) single crystal. The output power density of this device can reach up to 1.1 W/cm in vitro, which is 18 times higher than the previous record (60 mW/cm). After being implanted in the rat brain, under 1-MHz ultrasound with a safe intensity of 212 mW/cm, the as-developed device can produce an instantaneous effective output power of 280 μW, which can immediately activate the periaqueductal gray brain area. The rat electrophysiological experiments under anesthesia and behavioral experiments demonstrate that our wireless-powered device is well qualified for deep brain stimulation and analgesia applications. These encouraging results provide new insights into the development of implantable devices in the future.
为可植入生物医学设备提供无线电力是一个极具挑战性但又极为重要的技术问题。在此，我们介绍一种基于掺钐的Pb(MgNb)O-PbTiO（Sm-PMN-PT）单晶的新型可植入压电超声能量收集装置。该装置的体外输出功率密度可达1.1 W/cm²，比之前的记录（60 mW/cm²）高出18倍。植入大鼠大脑后，在强度为212 mW/cm²的1兆赫兹安全超声作用下，所开发的装置可产生280微瓦的瞬时有效输出功率，能够立即激活导水管周围灰质脑区。麻醉状态下的大鼠电生理实验和行为实验表明，我们的无线供电装置完全适用于深部脑刺激和镇痛应用。这些令人鼓舞的结果为未来可植入设备的发展提供了新的见解。
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