全身性滤过器官在衰老中的作用及其在返老还童策略中的潜力。

The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies.

机构信息

Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC H3A 2BA, Canada.

Department of Biomedical Sciences, College of Health Sciences-QU-Health, Qatar University, Doha 2713, Qatar.

出版信息

Int J Mol Sci. 2022 Apr 14;23(8):4338. doi: 10.3390/ijms23084338.

DOI:10.3390/ijms23084338

PMID:35457154

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9025381/

Abstract

Advances in aging studies brought about by heterochronic parabiosis suggest that agingmight be a reversable process that is affected by changes in the systemic milieu of organs andcells. Given the broadness of such a systemic approach, research to date has mainly questioned theinvolvement of "shared organs" versus "circulating factors". However, in the absence of a clearunderstanding of the chronological development of aging and a unified platform to evaluate thesuccesses claimed by specific rejuvenation methods, current literature on this topic remains scattered.Herein, aging is assessed from an engineering standpoint to isolate possible aging potentiators via ajuxtaposition between biological and mechanical systems. Such a simplification provides a generalframework for future research in the field and examines the involvement of various factors in aging.Based on this simplified overview, the kidney as a filtration organ is clearly implicated, for the firsttime, with the aging phenomenon, necessitating a re-evaluation of current rejuvenation studies tountangle the extent of its involvement and its possible role as a potentiator in aging. Based on thesefindings, the review concludes with potential translatable and long-term therapeutics for aging whileoffering a critical view of rejuvenation methods proposed to date.

摘要

衰老研究的进展表明，衰老可能是一个可逆转的过程，受到器官和细胞的系统环境变化的影响。鉴于这种系统方法的广泛性，迄今为止的研究主要质疑了“共享器官”与“循环因子”的参与。然而，在缺乏对衰老的时间发展的清晰理解以及评估特定抗衰老方法所声称的成功的统一平台的情况下，目前关于这个主题的文献仍然分散。在此，从工程学的角度评估衰老，通过将生物系统和机械系统并置来分离可能的衰老促进剂。这种简化为该领域的未来研究提供了一个通用框架，并研究了各种因素在衰老中的参与。基于这个简化的概述，肾脏作为一个过滤器官，首次与衰老现象明显相关，这需要重新评估当前的抗衰老研究，以理清其参与的程度及其作为衰老促进剂的可能作用。基于这些发现，该综述在为衰老提供潜在可转化和长期治疗方法的同时，对迄今为止提出的抗衰老方法提出了批判性的看法。