微小RNA-107通过靶向TRIAP1抑制胃癌细胞增殖。
miR-107 Inhibits the Proliferation of Gastric Cancer Cells and by Targeting TRIAP1.
作者信息
Yan Jiexin, Dai Lu, Yuan Jun, Pang Min, Wang Yueqiu, Lin Lang, Shi Yawei, Wu Fuli, Nie Rongping, Chen Qiuling, Wang Lei
机构信息
Emergency of Department, Changhai Hospital, Shanghai, China.
The Fourth Outpatient Department, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Front Genet. 2022 Apr 11;13:855355. doi: 10.3389/fgene.2022.855355. eCollection 2022.
Gastric cancer is a kind of gastrointestinal tumor with high morbidity and mortality. Finding effective methods for early diagnosis and treatment of gastric cancer has important significance and application prospects. MicroRNAs without protein coding potential affect the occurrence and development of gastric cancer. This study aims to explore the biological function and mechanism of microRNA-107 (miR-107) in gastric cancer. The results show that miR-107 is low expressed in gastric cancer, while TRIAP1 is highly expressed; the overexpression of miR-107 can inhibit the progression of gastric cancer and , while the overexpression plasmid of TRIAP1 can restore the miR-107 mimic-induced cell proliferation and metastasis inhibition, and the small interfering RNA of TRIAP1 can inhibit the cell proliferation and invasion induced by miR-107 inhibitor. In conclusion, the results of this study show that miR-107 can inhibit the proliferation of gastric cancer and by targeting TRIAP1.
胃癌是一种发病率和死亡率都很高的胃肠道肿瘤。寻找有效的胃癌早期诊断和治疗方法具有重要意义和应用前景。没有蛋白质编码潜能的微小RNA影响胃癌的发生和发展。本研究旨在探讨微小RNA-107（miR-107）在胃癌中的生物学功能及机制。结果显示，miR-107在胃癌中低表达，而TRIAP1高表达；miR-107过表达可抑制胃癌进展，而TRIAP1过表达质粒可恢复miR-107模拟物诱导的细胞增殖和转移抑制，TRIAP1的小干扰RNA可抑制miR-107抑制剂诱导的细胞增殖和侵袭。总之，本研究结果表明miR-107可通过靶向TRIAP1抑制胃癌增殖。
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