[视神经再生——终有一日会成为现实吗？]
[Regeneration of the optic nerve-Will it one day be reality?].
作者信息
Prokosch Verena, Liu Hanhan, Leibinger Marco, Fischer Dietmar
机构信息
Zentrum für Augenheilkunde, Medizinische Fakultät und Universität zu Köln, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
Zentrum für Pharmakologie, Medizinische Fakultät und Universität zu Köln, Uniklinik Köln, Paul-Schallück-Str. 8, 50937, Köln, Deutschland.
出版信息
Ophthalmologie. 2022 Sep;119(9):919-928. doi: 10.1007/s00347-022-01628-0. Epub 2022 May 2.
BACKGROUND
Adult mammalian and human neurons of the central nervous system (CNS) lack the ability to spontaneously regenerate damaged axons. This dilemma of many CNS diseases is still an unsolved problem.
OBJECTIVE
The purpose of this article is to examine the question which options have been investigated in more detail in recent years and offer approaches.
METHODS
A web-based search of all articles published between 1958 to the present regarding regeneration of retinal ganglion cells was carried out.
RESULTS
Over the last three decades it has been shown that axonal regeneration is possible under certain conditions when intrinsic and extrinsic factors are manipulated in retinal ganglion cells and in the optic nerve. Although there is still a long way to go, experimental regenerative approaches are already visible; however, it will take several years or decades before these can be approximately implemented in practice.
背景
成年哺乳动物和人类中枢神经系统（CNS）的神经元缺乏自发再生受损轴突的能力。许多中枢神经系统疾病面临的这一困境仍是一个未解决的问题。
目的
本文旨在探讨近年来哪些选项得到了更详细的研究，并提供相应方法。
方法
对1958年至今发表的所有关于视网膜神经节细胞再生的文章进行了基于网络的检索。
结果
在过去三十年中已经表明，当对视网膜神经节细胞和视神经中的内在和外在因素进行操控时，在某些条件下轴突再生是可能的。尽管仍有很长的路要走，但实验性的再生方法已经初见端倪；然而，要在实践中大致实现这些方法还需要数年或数十年时间。
Zotero 插件