镍催化γ-金属化酮与未活化烷基溴的还原偶联反应
Nickel-Catalyzed Reductive Coupling of γ-Metalated Ketones with Unactivated Alkyl Bromides.
作者信息
Cui Ning, Lin Tingzhi, Wang Yan-En, Wu Jian, Han Yuheng, Xu Xinyang, Xue Fei, Xiong Dan, Walsh Patrick J, Mao Jianyou
机构信息
Technical Institute of Fluorochemistry, Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, P. R. China.
Institute of Material Physics & Chemistry, College of Science, Nanjing Forestry University, Nanjing 210037, P. R. China.
出版信息
Org Lett. 2022 Jun 10;24(22):3987-3992. doi: 10.1021/acs.orglett.2c01390. Epub 2022 May 31.
A nickel-catalyzed reductive cross-coupling reaction of aryl cyclopropyl ketones with easily accessible unactivated alkyl bromides to access aryl alkyl ketones has been developed. This strategy facilitates access to various of γ-alkyl-substituted ketones via ring opening of cyclopropyl ketones (26 examples, 50-90% yield). Initial mechanistic studies revealed that the reaction proceeds via radical cleavage of the alkyl bromide.
已开发出一种镍催化的芳基环丙基酮与易于获得的未活化烷基溴的还原交叉偶联反应，以制备芳基烷基酮。该策略通过环丙基酮的开环促进了各种γ-烷基取代酮的合成（26个实例，产率50-90%）。初步机理研究表明，该反应通过烷基溴的自由基裂解进行。
Zotero 插件