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全髋关节置换术后阿片类药物使用的后果、政府策略及替代性疼痛控制技术

Opioid Use Consequences, Governmental Strategies, and Alternative Pain Control Techniques Following Total Hip Arthroplasties.

作者信息

Berardino Kevin, Carroll Austin H, Popovsky Daniel, Ricotti Robert, Civilette Matthew D, Sherman William F, Kaye Alan D

机构信息

Georgetown University School of Medicine.

George Washington University Hospital.

出版信息

Orthop Rev (Pavia). 2022 May 31;14(4):35318. doi: 10.52965/001c.35318. eCollection 2022.

Abstract

Over the last several decades, rates of opioid use and associated problems have dramatically increased in the United States leading to laws limiting prescription duration for acute pain management. As a result, orthopedic surgeons who perform total hip arthroplasty (THA), a procedure that often leads to significant postoperative pain, have been faced with substantial challenges to adequately mitigate patient pain while also reducing opioid intake. Current strategies include identifying and correcting modifiable risk factors associated with postoperative opioid use such as preoperative opioid use, alcohol and tobacco abuse, and untreated psychiatric illness. Additionally, recent evidence has emerged in the form of Enhanced Recovery After Surgery (ERAS) protocols suggesting that a multidisciplinary focus on patient factors perioperatively can lead to reduced postoperative opioid administration and decreased hospital stays. A cornerstone of ERAS protocols includes multimodal pain regimens with opioid rescue only as needed, which often includes multiple systemic pain therapies such as acetaminophen, gabapentin, non-steroidal anti-inflammatory drugs, as well as targeted pain therapies that include epidural catheters and ultrasound-guided nerve blocks. Many hospital systems and states have also implemented opioid prescribing limitations with mixed success. As the opioid epidemic continues in the United States, while contributing to poor outcomes following elective surgeries, further research is warranted to identify multidisciplinary strategies that mitigate opioid use while also allowing for adequate pain control and rehabilitation.

摘要

在过去几十年里,美国阿片类药物的使用量及相关问题急剧增加,这导致了限制急性疼痛管理处方时长的法律出台。因此,进行全髋关节置换术(THA)的骨科医生面临着巨大挑战,该手术常会导致严重的术后疼痛,他们既要充分减轻患者疼痛,又要减少阿片类药物的摄入量。当前的策略包括识别并纠正与术后阿片类药物使用相关的可改变风险因素,如术前阿片类药物使用、酗酒和吸烟以及未治疗的精神疾病。此外,以术后加速康复(ERAS)方案形式出现的最新证据表明,围手术期多学科关注患者因素可减少术后阿片类药物的使用并缩短住院时间。ERAS方案的一个基石包括按需使用阿片类药物进行解救的多模式疼痛治疗方案,这通常包括多种全身性疼痛治疗方法,如对乙酰氨基酚、加巴喷丁、非甾体抗炎药,以及包括硬膜外导管和超声引导神经阻滞在内的靶向疼痛治疗方法。许多医院系统和州也实施了阿片类药物处方限制,但成效不一。由于美国阿片类药物流行问题仍在持续,且导致择期手术后出现不良后果,因此有必要开展进一步研究,以确定多学科策略,在减轻阿片类药物使用的同时,还能实现充分的疼痛控制和康复。

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