持续性严重急性呼吸系统综合征冠状病毒 2 感染，伴有 HIV 感染控制不佳的患者体内病毒突变的积累。
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection.
机构信息
Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.
Department of Medicine, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa.
出版信息
Clin Infect Dis. 2023 Feb 8;76(3):e522-e525. doi: 10.1093/cid/ciac548.
Abstract
A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.
摘要
一名 22 岁的女性患有未控制的晚期人类免疫缺陷病毒 (HIV) 感染，持续感染严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的β变体长达 9 个月，病毒累计了超过 20 个额外的突变。抗逆转录病毒治疗抑制了 HIV，并在 6 至 9 周内清除了 SARS-CoV-2。需要加强警惕，以使受影响的个体受益，并防止新型 SARS-CoV-2 变体的出现。
相似文献
1
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection.
Clin Infect Dis. 2023 Feb 8;76(3):e522-e525. doi: 10.1093/cid/ciac548.
2
Association Between Human Immunodeficiency Virus Viremia and Compromised Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Beta Variant.
J Infect Dis. 2023 Jan 11;227(2):211-220. doi: 10.1093/infdis/jiac343.
3
Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.
Clin Infect Dis. 2022 Nov 30;75(11):2016-2018. doi: 10.1093/cid/ciac409.
4
Emergence of SARS-CoV-2 Spike Mutations during Prolonged Infection in Immunocompromised Hosts.
Microbiol Spectr. 2022 Jun 29;10(3):e0079122. doi: 10.1128/spectrum.00791-22. Epub 2022 May 11.
5
Analysis of type I IFN response and T cell activation in severe COVID-19/HIV-1 coinfection: A case report.
Medicine (Baltimore). 2020 Sep 4;99(36):e21803. doi: 10.1097/MD.0000000000021803.
6
SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA.
Emerg Infect Dis. 2021;27(10):2720-2723. doi: 10.3201/eid2710.211461. Epub 2021 Jul 23.
7
Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection: A Systematic Review of the Literature and Challenges.
AIDS Res Hum Retroviruses. 2021 Apr;37(4):266-282. doi: 10.1089/AID.2020.0284. Epub 2021 Mar 23.
8
An HIV-infected patient with coronavirus disease 2019 has a favourable prognosis: a case report.
Ann Palliat Med. 2021 May;10(5):5808-5812. doi: 10.21037/apm-20-576. Epub 2020 Aug 10.
9
Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines.
Curr HIV/AIDS Rep. 2022 Feb;19(1):5-16. doi: 10.1007/s11904-021-00590-x. Epub 2021 Nov 29.
10
Persistent infection with severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a patient with untreated human immunodeficiency virus (HIV).
Infect Control Hosp Epidemiol. 2023 Feb;44(2):350-351. doi: 10.1017/ice.2022.140. Epub 2022 May 20.
引用本文的文献
1
Persistent innate immune dysfunction and ZIKV replication in the gastrointestinal tract during SIV infection in pigtail macaques.
Front Immunol. 2025 Mar 4;16:1535807. doi: 10.3389/fimmu.2025.1535807. eCollection 2025.
2
The consequences of SARS-CoV-2 within-host persistence.
Nat Rev Microbiol. 2025 May;23(5):288-302. doi: 10.1038/s41579-024-01125-y. Epub 2024 Nov 25.
3
Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection.
PLoS Pathog. 2024 Oct 15;20(10):e1012624. doi: 10.1371/journal.ppat.1012624. eCollection 2024 Oct.
4
The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection.
Viruses. 2024 Jul 21;16(7):1173. doi: 10.3390/v16071173.
5
Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation.
Nat Commun. 2024 Mar 15;15(1):2360. doi: 10.1038/s41467-024-46673-2.
6
SARS-CoV-2 evolution during prolonged infection in immunocompromised patients.
mBio. 2024 Mar 13;15(3):e0011024. doi: 10.1128/mbio.00110-24. Epub 2024 Feb 16.
7
SARS-CoV-2 infection in immunosuppression evolves sub-lineages which independently accumulate neutralization escape mutations.
Virus Evol. 2023 Dec 28;10(1):vead075. doi: 10.1093/ve/vead075. eCollection 2024.
8
Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report.
Virol J. 2024 Jan 4;21(1):8. doi: 10.1186/s12985-023-02278-7.
9
Rapid dynamic changes of FL.2 variant: A case report of COVID-19 breakthrough infection.
Int J Infect Dis. 2024 Jan;138:91-96. doi: 10.1016/j.ijid.2023.11.011. Epub 2023 Nov 11.
10
Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease.
Front Immunol. 2023 Sep 27;14:1250198. doi: 10.3389/fimmu.2023.1250198. eCollection 2023.
Zotero 插件