基于芯片的多重分析评估姜黄素对 COVID-19 细胞因子风暴的影响。
Evaluating the Effects of Curcumin on the Cytokine Storm in COVID-19 Using a Chip-Based Multiplex Analysis.
机构信息
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Methods Mol Biol. 2022;2511:285-295. doi: 10.1007/978-1-0716-2395-4_21.
SARS-CoV-2 can stimulate the expression of various inflammatory cytokines and induce the cytokine storm in COVID-19 patients leading to multiple organ failure and death. Curcumin as a polyphenolic compound has been shown to have anti-inflammatory properties and inhibit the release of numerous pro-inflammatory cytokines. We present multiplex analysis using the Evidence Investigator biochip system to determine the effect of curcumin on serum level of cytokines which are typically elevated in cytokine storm events, including tumor necrosis factor (TNF-α), interleukin 6 (IL-6), and IL-10.
SARS-CoV-2 可刺激各种炎症细胞因子的表达，并在 COVID-19 患者中引发细胞因子风暴，导致多器官衰竭和死亡。姜黄素作为一种多酚化合物，已被证明具有抗炎特性，并能抑制多种促炎细胞因子的释放。我们使用 Evidence Investigator 生物芯片系统进行多重分析，以确定姜黄素对细胞因子血清水平的影响，这些细胞因子通常在细胞因子风暴事件中升高，包括肿瘤坏死因子 (TNF-α)、白细胞介素 6 (IL-6) 和白细胞介素 10 (IL-10)。
Zotero 插件