对抗抗菌药物耐药性的噬菌体产品
Phage Products for Fighting Antimicrobial Resistance.
作者信息
Huang Yuanling, Wang Wenhui, Zhang Zhihao, Gu Yufeng, Huang Anxiong, Wang Junhao, Hao Haihong
机构信息
National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China.
MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
出版信息
Microorganisms. 2022 Jun 30;10(7):1324. doi: 10.3390/microorganisms10071324.
Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for a new method to combat AMR and phages are viruses that can effectively fight bacterial infections, which have renewed interest as antibiotic alternatives with their specificity. Large phage products have been produced in recent years to fight AMR. Using the "one health" approach, this review summarizes the phage products used in plant, food, animal, and human health. In addition, the advantages and disadvantages and future perspectives for the development of phage therapy as an antibiotic alternative to combat AMR are also discussed in this review.
抗菌耐药性（AMR）已成为一个全球公共卫生问题，而抗生素药物在应对细菌耐药性的上升方面已显滞后。我们正在寻找一种对抗AMR的新方法，噬菌体是能够有效对抗细菌感染的病毒，因其特异性而作为抗生素替代品重新引发了人们的兴趣。近年来已生产出大型噬菌体产品来对抗AMR。本综述采用“同一健康”方法，总结了用于植物、食品、动物和人类健康领域的噬菌体产品。此外，本综述还讨论了噬菌体疗法作为对抗AMR的抗生素替代品发展的优缺点及未来前景。
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