Advances in delivery methods of (spirulina) for enhanced therapeutic outcomes.

() aqueous extract has massive amounts of natural products that can be used as future drugs, such as C-phycocyanin, allophycocyanin, etc. This extract was chosen because of its high adaptability, which reflects its resolute genetic composition. The proactive roles of cyanobacteria, particularly in the medical field, have been discussed in this review, including the history, previous food and drug administration (FDA) reports, health benefits and the various dose-dependent therapeutic functions that possesses, including its role in fighting against lethal diseases such as cancer, SARS-CoV-2/COVID-19, etc. However, the remedy will not present its maximal effect without the proper delivery to the targeted place for deposition. The goal of this research is to maximize the bioavailability and delivery efficiency of constituents through selected sites for effective therapeutic outcomes. The solutions reviewed are mainly on parenteral and tablet formulations. Moreover, suggested enteric polymers were discussed with minor composition variations applied for better storage in high humid countries alongside minor variations in the polymer design were suggested to enhance the premature release hindrance of basic drugs in low pH environments. In addition, it will open doors for research in delivering active pharmaceutical ingredients (APIs) in femtoscale with the use of various existing and new formulations. SDGs; , IL-4; , HDL; , LDL; , VLDL; , C-PC; , APC; , PE; , COX-2; , RCTs; , TNF-α; , γ-LFA; , PGs; , PUFAs: , NK-cell; , FDA; , GRAS; , SD; , API; , DW; , IM; , IV; , ID; , SC; , AERs; , DSI-EC; , cGMP; , Spirulina sp.; species, , Tecuitlatl; , CRC; , HDI; , Tf; , TfR; , FR; , CPP; , SUV; , LUV; , GUV; , MLV; , COVID-19; , PEGylated; , PEG; , OSCEs; , GI; , CAP; , HPMCP, , SR; , DR; , Poly(MA-EA); -DR L-30 D-55; , MW; , T; , SN; , EPR; , VEGF; , RGD; , VCAM-1; , P; , PES; , pH; , ζ-potential; , NTA; , PB; , DLS; , AFM; , Log P; , MR; , tPSA; , C log P; , CMR; , Log S; , pka; , DDAB; , DOPE; , GDP; , RES; , PKU; , MS; , SLE; , NASA; , DOX; , ADRs; , SVM; , MDA; , TBARS; , CRP; , CK; , LDH; , T2D; , PCB; , PBP; , PEB; , DPP-4; , MTT; , IL-2; , IL-6; , PRISMA; , STATA; , HepG2; , HCT116; , Kasumi-1; , K562; , Se-PC; , MCF-7; , A375; , RAS; , IQP; , VEP; , M; , PL; , BMI; , IC; , LD; , PC12 Adh; , RNS; , Hb1Ac; .